Familial Cancer

, Volume 5, Issue 1, pp 3–13

Partnering in Oncogenetic Research – The INHERIT BRCAs Experience: Opportunities and Challenges

Authors

    • Centre de Recherche en Droit Public, Faculty of LawUniversity of Montreal
    • Centre de Recherche en Droit Public, Faculty of LawUniversity of Montreal
  • Peter Bridge
    • Molecular Diagnostic Laboratory, Alberta Children’s Hospital, Departments of Medical Genetics and Pathology, Faculty of MedicineUniversity of Calgary
  • Lucie M. Bucci
    • Centre de Recherche en Droit Public, Faculty of LawUniversity of Montreal
  • Jocelyne Chiquette
    • Clinique des Maladies du Sein Deschênes-FabiaHôpital du Saint-Sacrement
  • Michel Dorval
    • Unité de Recherche en Santé des Populations, CHA Research Center, Hôpital du Saint-Sacrement, Faculty of PharmacyLaval University
  • Francine Durocher
    • Cancer Genomics Laboratory, CHUL Research Centre, CHUQ, Department of Anatomy and Physiology, Faculty of MedicineLaval University
  • Doug Easton
    • CRC Genetic Epidemiology Unit, Strangeways Research LaboratoriesUniversity of Cambridge
  • Béatrice Godard
    • Centre de Recherche en Droit Public, Faculty of LawUniversity of Montreal
    • Faculty of MedicineUniversity of Montreal
  • David Goldgar
    • Genetic Epidemiology Unit, International Agency for Research on CancerWorld Health Organization
  • Bartha Maria Knoppers
    • Centre de Recherche en Droit Public, Faculty of LawUniversity of Montreal
    • Canada Research Chair in Law and Medicine
  • Rachel Laframboise
    • Clinical Genetics Division, Department of Paediatrics and Medicine, CHUL, CHUQ, Faculty of MedicineLaval University
  • Bernard Lespérance
    • Department of Haemato-Oncology, Hôpital du Sacré-Coeur de Montréal, Faculty of MedicineUniversity of Montreal
  • Marie Plante
    • Gynaecology Service, Gynaecologic Oncology Division, Hôtel-Dieu de Québec, CHUQ, Department of Obstetrics and Gynaecology, Faculty of MedicineLaval University
  • Sean V. Tavtigian
    • Unit of Genetic Cancer Susceptibility, International Agency for Research on CancerWorld Health Organization
  • Hélène Vézina
    • Department of Human Sciences, Interdisciplinary Research Group in Genetic Demography and Epidemiology (GRIG)Université du Québec à Chicoutimi
  • Brenda Wilson
    • Department of Epidemiology and Community MedicineUniversity of Ottawa
  • INHERIT BRCAs
  • Jacques Simard
    • Cancer Genomics Laboratory, CHUL Research Centre, CHUQ, Department of Anatomy and Physiology, Faculty of MedicineLaval University
    • Canada Research Chair in Oncogenetics
Article

DOI: 10.1007/s10689-005-2570-8

Cite this article as:
Avard, D., Bridge, P., Bucci, L.M. et al. Familial Cancer (2006) 5: 3. doi:10.1007/s10689-005-2570-8

Abstract

Today it is common to conduct research in collaboration with colleagues from different disciplines and institutions. The INterdisciplinary HEalth Research International Team on BReast CAncer susceptibility (INHERIT BRCAs), involves Canadian and international experts from diverse fields working with health service providers, patients and collaborators from the World Health Organization and other European networks. Evidence-based information and knowledge transfer drive our efforts to advance genomic research to understand the genetic basis of cancer susceptibility and treatment response. Several goals reveal the interdisciplinary team approach: (a) to estimate the prevalence and penetrance of BRCA1 and BRCA2 mutations and their deleterious impact upon different populations; (b) to pinpoint novel breast cancer susceptibility loci; (c) to assess the efficacy of clinical interventions; (d) to address changes in quality of life and health-related behaviour from the decision to undergo genetics testing and during follow-up; (e) to evaluate legal, social and ethical implications; and, finally; (f) to promote professional and public education by facilitating the transfer of research findings to clinical practice and informing policy makers. The lessons learned by the INHERIT research team and future challenges are presented.

Keywords

academic teams clinical practice collaboration familial cancer genetics hereditary cancer interdisciplinary knowledge translation research

Copyright information

© Springer 2006