Familial Cancer

, Volume 4, Issue 3, pp 249–254

Gynecologic Cancers in Lynch Syndrome/HNPCC


DOI: 10.1007/s10689-005-1838-3

Cite this article as:
Lu, H.K. & Broaddus, R.R. Familial Cancer (2005) 4: 249. doi:10.1007/s10689-005-1838-3


Recent studies have estimated that the lifetime risk of endometrial cancer in women with Lynch syndrome/hereditary non-polyposis colorectal cancer syndrome (Lynch/HNPCC) is 40–60%. This risk equals or exceeds their risk for colon cancer. While much research has been done to define the natural history and molecular features of Lynch/HNPCC associated colon cancer, there has been considerably less research defining Lynch/HNPCC associated endometrial cancer. This article will review current information regarding the clinico-pathologic features of Lynch/HNPCC associated endometrial cancer. In addition, current consensus guidelines for endometrial cancer screening and prevention for women with Lynch/HNPCC will be discussed. Given the increased risk of multiple cancers, changing the name of this syndrome from hereditary non-polyposis colorectal cancer syndrome to Lynch Syndrome may benefit both patients and clinicians. Clinicians caring for women with Lynch/HNPCC may stress colon cancer screening and prevention without reviewing endometrial cancer risks and symptoms or screening and prevention options. Perhaps more importantly, women with Lynch/HNPCC may focus on colon cancer risks and lack understanding of endometrial cancer risks. With increasing evidence that women with Lynch/HNPCC have significant risks for both colon and endometrial cancers, we believe a multi-disciplinary approach to the management of these individuals is crucial.

Key words

endometrial cancerHNPCC-Lynch syndromeovarian cancer

Copyright information

© Springer 2005

Authors and Affiliations

  1. 1.Department of Gynecologic OncologyUT MD Anderson Cancer CenterHoustonUSA
  2. 2.Department of PathologyUT MD Anderson Cancer CenterHoustonUSA