European Journal of Epidemiology

, Volume 26, Issue 11, pp 833–850

Wine, beer or spirit drinking in relation to fatal and non-fatal cardiovascular events: a meta-analysis

  • Simona Costanzo
  • Augusto Di Castelnuovo
  • Maria Benedetta Donati
  • Licia Iacoviello
  • Giovanni de Gaetano
REVIEW

DOI: 10.1007/s10654-011-9631-0

Cite this article as:
Costanzo, S., Di Castelnuovo, A., Donati, M.B. et al. Eur J Epidemiol (2011) 26: 833. doi:10.1007/s10654-011-9631-0

Abstract

In previous studies evaluating whether different alcoholic beverages would protect against cardiovascular disease, a J-shaped relationship for increasing wine consumption and vascular risk was found; however a similar association for beer or spirits could not be established. An updated meta-analysis on the relationship between wine, beer or spirit consumption and vascular events was performed. Articles were retrieved through March 2011 by PubMed and EMBASE search and a weighed least-squares regression analysis pooled data derived from studies that gave quantitative estimation of the vascular risk associated with the alcoholic beverages. From 16 studies, evidence confirms a J-shaped relationship between wine intake and vascular risk. A significant maximal protection—average 31% (95% confidence interval (CI): 19–42%) was observed at 21 g/day of alcohol. Similarly, from 13 studies a J-shaped relationship was apparent for beer (maximal protection: 42% (95% CI: 19–58%) at 43 g/day of alcohol). From 12 studies reporting separate data on wine or beer consumption, two closely overlapping dose–response curves were obtained (maximal protection of 33% at 25 g/day of alcohol). This meta-analysis confirms the J-shaped association between wine consumption and vascular risk and provides, for the first time, evidence for a similar relationship between beer and vascular risk. In the meta-analysis of 10 studies on spirit consumption and vascular risk, no J-shaped relationship could be found.

Keywords

Meta-analysisAlcoholCardiovascular diseaseMortality

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Simona Costanzo
    • 1
  • Augusto Di Castelnuovo
    • 1
  • Maria Benedetta Donati
    • 1
  • Licia Iacoviello
    • 1
  • Giovanni de Gaetano
    • 1
  1. 1.Laboratory of Genetic and Environmental EpidemiologyResearch Laboratories, Fondazione di Ricerca e Cura “Giovanni Paolo II”CampobassoItaly