CHRONIC DISEASES

European Journal of Epidemiology

, Volume 24, Issue 9, pp 553-572

Open Access This content is freely available online to anyone, anywhere at any time.

The Rotterdam Study: 2010 objectives and design update

  • Albert HofmanAffiliated withDepartment of Epidemiology, Erasmus Medical Center Email author 
  • , Monique M. B. BretelerAffiliated withDepartment of Epidemiology, Erasmus Medical Center
  • , Cornelia M. van DuijnAffiliated withDepartment of Epidemiology, Erasmus Medical Center
  • , Harry L. A. JanssenAffiliated withDepartment of Internal Medicine, Erasmus Medical Center
  • , Gabriel P. KrestinAffiliated withDepartment of Radiology, Erasmus Medical Center
  • , Ernst J. KuipersAffiliated withDepartment of Internal Medicine, Erasmus Medical Center
  • , Bruno H. Ch. StrickerAffiliated withDepartment of Epidemiology, Erasmus Medical CenterDepartment of Internal Medicine, Erasmus Medical Center
  • , Henning TiemeierAffiliated withDepartment of Epidemiology, Erasmus Medical Center
  • , André G. UitterlindenAffiliated withDepartment of Epidemiology, Erasmus Medical CenterDepartment of Internal Medicine, Erasmus Medical Center
    • , Johannes R. VingerlingAffiliated withDepartment of Epidemiology, Erasmus Medical CenterDepartment of Ophthalmology, Erasmus Medical Center
    • , Jacqueline C. M. WittemanAffiliated withDepartment of Epidemiology, Erasmus Medical Center

Abstract

The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. The findings of the Rotterdam Study have been presented in close to a 1,000 research articles and reports (see www.​epib.​nl/​rotterdamstudy). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.

Keywords

Biomarkers Cardiovascular diseases Cohort study Endocrine diseases Epidemiologic methods Genetic epidemiology Liver diseases Neurological diseases Ophthalmic diseases Pharmacoepidemiology Psychiatric diseases Respiratory diseases