European Journal of Epidemiology

, Volume 25, Issue 1, pp 45–53

Nitric oxide and clustering of metabolic syndrome components in pediatrics

Authors

  • Asghar Ghasemi
    • Endocrine Research Center, Research Institute for Endocrine SciencesShahid Beheshti University of Medical Sciences
    • Endocrine Research Center, Research Institute for Endocrine SciencesShahid Beheshti University of Medical Sciences
  • Fereidoun Azizi
    • Endocrine Research Center, Research Institute for Endocrine SciencesShahid Beheshti University of Medical Sciences
PEDIATRIC EPIDEMIOLOGY

DOI: 10.1007/s10654-009-9382-3

Cite this article as:
Ghasemi, A., Zahediasl, S. & Azizi, F. Eur J Epidemiol (2010) 25: 45. doi:10.1007/s10654-009-9382-3

Abstract

This study was performed to determine the risk factor pattern of the metabolic syndrome (MetS) in association with serum nitric oxide metabolites (NO x ) in children and adolescents. The study included 851 children and adolescents, aged 4–19 years. The MetS was defined according to modified Adult treatment Panel III criteria. Cluster analysis was performed using principle components analysis with varimax orthogonal rotation to examine the risk factor pattern of the MetS. The prevalence of MetS was 10.8 and 10.0% in males and females, respectively. Age-and sex-adjusted odds ratio of having MetS was significantly higher in the upper quartile of NO x compared to the lower quartile (2.2, 95% CI: 1.1–4.7, p = 0.029). In the whole population, three factors were identified including blood pressure/obesity, lipid/obesity, and glucose/NO x . Stratifying for sex, again three factors were retained; however, in males NO x was loaded in two factors. In conclusion, serum NO x was associated and loaded with other MetS components in cluster analysis of metabolic risk factors.

Keywords

Adolescent Child Metabolic syndrome Nitric oxide Obesity

Abbreviations

ATPIII

Adult Treatment Panel III

BP

Blood pressure

CI

Confidence interval

CVD

Cardiovascular disease

DBP

Diastolic blood pressure

eNOS

Endothelial nitric oxide synthase

FPG

Fasting plasma glucose

HDL-C

High-density lipoprotein cholesterol

iNOS

Inducible nitric oxide synthase

MetS

Metabolic syndrome

MONICA

Monitoring of trends and determinants in cardiovascular disease

mRNA

Messenger ribonucleic acid

MSA

Measure of sampling adequacy

NO

Nitric oxide

NO x

Nitric oxide metabolites

SBP

Systolic blood pressure

TC

Total cholesterol

TG

Triglycerides

TLGS

Tehran Lipid and Glucose Study

WC

Waist circumference

WHO

World Health Organization

WHR

Waist-to-hip ratio

Copyright information

© Springer Science+Business Media B.V. 2009