Sex differential in mortality trends of old-aged Danes: a nation wide study of age, period and cohort effects
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- Jacobsen, R., Oksuzyan, A., Engberg, H. et al. Eur J Epidemiol (2008) 23: 723. doi:10.1007/s10654-008-9288-5
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Objective Over the last half century the mortality rates in Denmark for females above age 80 have declined dramatically whereas the decline for males have been modest, resulting in a change in sex-ratio for centenarians from 2 to 5. Here we investigate whether this mortality pattern is mainly explained by period effects, cohort effects or both. This can provide clues for where to search for causes behind the changes in sex differential in mortality seen in many Western countries during the last decades. Methods Age-period-cohort study of mortality for all Danish women and men aged 79–98 during the period 1949–2006. Outcome measures Relative risks for deaths and second order differences for exploration of the nonlinear variation. Results Both the overall trends in mortality differences and the fluctuations in mortality for both men and women were better explained by period effects than by cohort effects. The observed rates were better described by the age, period and cohort model than by other models. Conclusions Our results suggest that causes for both the overall increased difference in mortality and the short term fluctuations in mortality rates are primarily to be found in the period dimension. Cohort effects on the mortality of the oldest Danish women and men played a significant but minor role compared to period effects.
KeywordsAge-period-cohort modeling Old age mortality Sex differential Denmark
There is a sex differential in mortality in favor of women all over the world and most pronounced in Western world countries [1, 2]. With economic development and improved living conditions for females, the sex gap in mortality favoring women has been increasing through the first three quarters of the twentieth century in most Western countries [3, 4, 5], including Denmark and other Nordic countries [6, 7]. However, findings of sex differences in mortality development in the developed countries during the last quarter of the twentieth century have been mixed. Female–male differences in life expectancy narrowed in most European countries and in the US from 1980 to 1996, but the sex gap became even larger in other countries such as Greece, Hungary, Russian Federation and Japan [8, 9, 10].
A number of explanations proposed to explain sex differences in mortality are rooted in biological, psychological, and social interpretations. Among the most prominent biological explanations are the hormonal, autoimmune and genetic explanations . The observation that males have a rise in cardiovascular disease approximately 10 years before females combined with the known favorable effect of estrogen on serum lipids  and its protective effect on brain cells  and consequent prevention of degenerative processes, has led to the hypothesis that estrogen is a central factor in the paradox. According to the X-chromosome hypothesis, the lack of a second X chromosome in the male is associated with increased mortality [11, 14]. Finally, the “immunocompetence” hypothesis states that increased male mortality throughout life may be caused in part by a greater susceptibility of males to infections [15, 16].
The social and behavioral factors, such as differences in social roles and behaviors, illness behavior, physician behavior and behavior related to health care utilization, have also been suggested to explain female–male differences in mortality . Research has consistently demonstrated that men engaged more frequently in higher risk-taking behavior such as cigarette smoking, higher alcohol consumption, more frequent use of psychoactive substances, and less safe driving that contributed to an increased risk of coronary heart disease (CHD), lung cancer, chronic obstructive pulmonary diseases, liver cirrhosis, and accident fatalities in men compared to women . There is a general agreement that cigarette smoking is the single largest identifiable factor in explaining increasing sex gap in mortality, but it is well established also that cigarette smoking alone cannot fully explain the sex difference in and the trajectories of mortality. The simple observation that there is still a sex difference in survival among never-smokers illustrates this [8, 9, 10]. Besides, recently it was found that the traditional risk factors for increased mortality such as social position and education had no or only very limited effect on the oldest-old mortality in Denmark .
For both men and women living in developed countries there has been a marked increase in life expectancy during the last century, especially at older ages [20, 21, 22, 23]. The number of centenarians has increased steadily in most developed countries [24, 25, 26]. The reason for the improvement in longevity seems mostly to be due to a reduction in mortality at advanced ages [27, 28, 29, 30]. It has recently been debated whether mostly cohort effects or period effects are responsible for this increase in longevity [31, 32]. Cohort effects are effects acting on specific generations whereas period effects act on more age groups living at a specific point in time. The ‘period hypothesis on longevity’ argues that changes in period effects acting at advances old age are the reason for the decrease in mortality seen in the many countries in the Western world during the last decades . The Barker hypothesis  or the ‘diminished entelechy hypothesis’  suggest that somatic insults in intrauterine life and early childhood predispose to increased morbidity and mortality in adulthood. The ‘inflammatory cohort hypothesis on longevity’ states that inflammatory exposure in childhood is associated with increased mortality at old age, and that the decrease in inflammatory exposure in childhood during the lasts centuries with each consecutive birth cohort is the reason for the observed reduction in mortality at advanced ages .
In this study we compared the mortality pattern of Danish women with that of Danish men to examine the increased sex differential in late life mortality during recent decades. We addressed the question if mostly period effects or cohort effects act on late life mortality patterns. In the search for causes behind the trends in the sex differential in mortality and in overall late life mortality it would be informative to know whether these causes are to be searched for in a period or a cohort perspective. If period effects are dominant, causes acting at the particular point in time should be searched for, whereas cohort effects point towards causes clustered to specific generations. For example, if inflammatory diseases in childhood in a given birth cohort are associated with old age mortality for that cohort, the mortality for men and women in the same cohort would be expected to show similar patterns if inflammatory diseases were not sex-specific.
Number of deaths and mid-year population, stratified by 1-year groups, for all Danish women and men aged 79–98 in the period 1949–2006 was obtained from the human mortality database . The reason for choosing this age range was that information on population size was only available until age 98 and when using 2-year categories for age, the starting point became 79 years. The data were organised in a two-way table with rows as 2-year age groups and columns as 2-year-period groups and approximate birth cohorts represented by the diagonals of the table. Within the 2-year age and period groups, the persons contributing to such a cohort were born within a 4-year-period, and the same persons contributed to two adjacent approximate birth cohorts.
Plots of observed mortality rates stratified by 2-year age groups and by sex were made in order to examine if the offset for the increased sex differential in mortality rates was initiated at the same point in time for all age groups (indicating a period effect) or if it was delayed by 2 years with each consecutive age group (indicating a cohort effect).
Formal goodness-of-fit analysis comparing the observed deviance to the relevant χ2-distribution requires some care for these data based on a complete national population, as conventional significance levels are not necessarily helpful, as these analyses were developed for relatively small sample sizes. This problem was approached by plotting expected rates based on the different models and the observed mortality rates.
Model fit for the different models
The overall patterns of the sex differential in mortality of the oldest old Danes suggest a strong influence of both nonlinear and linear period effects. The same offset over age categories is observed and the formal representation in different models points mostly towards causes acting in the period dimension for the marked increase in sex differential in mortality since the 1960s. Cohort effects increased the overall formal fit when included in the model. Also, the inclusion of cohort resulted in a slightly better fit when evaluating observed and expected rates, signifying some influence of cohort effects on the nonlinear variation in the sex-specific mortality. However, generally the overall increase in the fit by including period was much larger than when including cohort. This suggests that a future search for underlying causes for sex differentials in old age mortality in Denmark should mostly focus on causes acting in the period dimension for both nonlinear and linear effects.
Whereas the nonlinear variation in cohort effects has previously been shown to have a large effect on the mortality of middle-aged women in Denmark , such effects seem to have diminished in old age. This supports the finding/assumption that cohort effects are reduced in old age as suggested by Kannisto .
The nonlinear patterns for men and women represented by second order differences had very similar patterns when shown in the period dimension, and limited or no similarities when presented in the cohort dimension. This is opposite to what is suggested by the ‘inflammatory cohort hypothesis on longevity’  which would predict similar nonlinear mortality patterns for cohorts of men and women exposed to the same inflammatory stimuli at childhood.
The study showed that even with the well-known unidentifiability problems in the age-period-cohort analysis due to the perfect correlation when all three are included in the model, an exploration in this framework can provide useful information on where to search for causes for observed mortality patterns, especially when short term fluctuations are seen in the mortality patterns (e.g. between years or cohorts). The credibility of age-period-cohort modeling in the analysis of mortality in Denmark has previously been shown  together with the possibility to compare more nations in the analysis . For future analysis of sex differentials in mortality it could be supportive to use the multinational method to elude differences among countries, and this might provide further clues on which causes are acting on late life mortality.
In conclusion, the age-period-cohort analysis has, in this study, proved useful as a tool for testing hypothesis addressing influences of period and cohort. The findings in this study suggest that causal factors acting on sex differentials in mortality at old age are mostly to be searched for in the given period.