European Journal of Epidemiology

, Volume 23, Issue 2, pp 115–122

Chronic obstructive pulmonary disease and mortality following hip fracture: a population-based cohort study

  • Cynthia de Luise
  • Michael Brimacombe
  • Lars Pedersen
  • Henrik Toft Sørensen

DOI: 10.1007/s10654-007-9211-5

Cite this article as:
de Luise, C., Brimacombe, M., Pedersen, L. et al. Eur J Epidemiol (2008) 23: 115. doi:10.1007/s10654-007-9211-5


Introduction: Mortality rates after hip fracture have not declined in 20 years. We assessed the impact of chronic obstructive pulmonary disease (COPD) on mortality after hip fracture, and compared mortality in this cohort to persons without hip fracture in a population-based prospective cohort study. Methods: Using Danish health care registries, we identified persons ≥40 years old with first-time hospitalization for hip fracture between 1/1/1998 and 1/31/2003. Hospitalization for COPD was assessed from hospital discharge registries. Using Cox regression, we computed relative risks (RR) and 95% confidence intervals (CI) for mortality endpoints among persons with COPD compared to persons without COPD. Mortality following hip fracture was also compared to age and gender matched controls without hip fracture. Results: We identified 11, 985 persons with first-time hospitalization for hip fracture; 771 (6.4%) had a diagnosis of COPD. Average follow up was 22 months. Compared to persons without COPD, mortality following hip fracture in persons with COPD was RR = 1.58 (95% CI 1.30–1.90) at 30 days, RR = 1.52 (95% CI 1.30–1.77) at 90–days, RR = 1.58 (95% CI 1.40–1.78) at 1 year, and RR = 1.71 (95% CI 1.55–1.88) overall. The 1-year mortality in persons with hip fracture and COPD was approximately 3–5 times greater than in controls without hip fracture. Conclusions: In this cohort, persons with COPD have a 60–70% higher risk of death following hip fracture than those without COPD. In addition, hip fracture and COPD increased 1-year mortality 3–5 times that of persons without hip fracture.


Chronic obstructive pulmonary disease Denmark Epidemiology Hip fracture Mortality Predictors 



Attributable risk


Anatomical therapeutic chemical


Confidence interval


Chronic obstructive pulmonary disease


International classification of disease




Relative risk


Standard error

Supplementary material

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Cynthia de Luise
    • 1
    • 2
  • Michael Brimacombe
    • 3
  • Lars Pedersen
    • 4
  • Henrik Toft Sørensen
    • 4
    • 5
  1. 1.Department of EpidemiologyUniversity of Medicine and Dentistry of New Jersey (UMDNJ) School of Public HealthNewarkUSA
  2. 2.EpidemiologyPfizer IncNew YorkUSA
  3. 3.New Jersey Medical School and School of Public Health, Department of Preventive Medicine and Community HealthUniversity of Medicine and Dentistry of New Jersey (UMDNJ)NewarkUSA
  4. 4.Department of Clinical EpidemiologyAarhus University HospitalAarhusDenmark
  5. 5.Department of EpidemiologyBoston UniversityBostonUSA

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