European Journal of Epidemiology

, Volume 22, Issue 8, pp 557–564

A possible association between maternal glomerulonephritis and congenital intestinal atresia/stenosis—a population-based case–control study

  • Nándor Ács
  • Ferenc Bánhidy
  • Erzsébet H. Puhó
  • Andrew E. Czeizel
Perinatal Epidemiology

DOI: 10.1007/s10654-007-9143-0

Cite this article as:
Ács, N., Bánhidy, F., Puhó, E.H. et al. Eur J Epidemiol (2007) 22: 557. doi:10.1007/s10654-007-9143-0


The objective of the study was to estimate association between maternal glomerulonephritis during pregnancy and structural birth defects, i.e. congenital abnormalities. The prevalence of maternal glomerulonephritis during the first trimester of pregnancy in cases with different congenital abnormalities was compared to that of matched controls without congenital abnormalities in the population-based Hungarian Case–Control Surveillance System of Congenital Abnormalities. Of 22,843 cases with congenital abnormalities, 309 (1.35%) had mothers with glomerulonephritis during pregnancy, compared to 479 (1.26%) of 38,151 controls (adjusted POR with 95% CI = 1.0, 0.9–1.2). Specified groups of congenital abnormalities were also assessed versus controls. Cases with isolated intestinal atresia/stenosis (adjusted POR with 95% CI: 6.8, 1.3–37.4) based on five cases were more likely to have mothers with prospectively and medically recorded glomerulonephritis. In conclusion a higher rate of congenital isolated intestinal atresia/stenosis may be associated with the maternal glomerulonephritis. However, this finding is considered only as signal and further studies are needed to confirm or reject this possible association.


GlomerulonephritisPregnancyMaternal effectCongenital abnormalitiesIntestinal atresia/stenosisCase–control study



Congenital abnormality


Confidence interval


Hungarian Congenital Abnormality Registry


Hungarian Case–Control Surveillance of Congenital Abnormalities




Prevalence odds ratio

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Nándor Ács
    • 1
  • Ferenc Bánhidy
    • 1
  • Erzsébet H. Puhó
    • 2
    • 3
  • Andrew E. Czeizel
    • 2
    • 4
  1. 1.Second Department of Obstetrics and Gynecology, School of MedicineSemmelweis UniversityBudapestHungary
  2. 2.Foundation for the Community Control of Hereditary DiseasesBudapestHungary
  3. 3.Department of Human Genetics and TeratologyNational Center for EpidemiologyBudapestHungary
  4. 4.BudapestHungary