European Journal of Epidemiology

, 22:129

EPIC-Heart: The cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries

Authors

    • EPIC-Heart Secretariat, Department of Public Health and Primary Care, Strangeways Research LaboratoryUniversity of Cambridge
  • Rodolfo Saracci
    • International Agency for Research on Cancer — WHO
  • Göran Berglund
    • Department of Clinical Sciences, MalmöUniversity of Lund
  • Edith Feskens
    • Division of Human NutritionWageningen University
  • Kim Overvad
    • Department of Clinical Epidemiology, Aalborg HospitalAarhus University Hospital
  • Salvatore Panico
    • Department of Clinical and Experimental MedicineFederico II University
  • Simon Thompson
    • MRC Biostatistics Unit, Institute of Public HealthUniversity of Cambridge
  • Agnès Fournier
    • Inserm ERI20, Institut Gustave Roussy
  • Françoise Clavel-Chapelon
    • Inserm ERI20, Institut Gustave Roussy
  • Marianne Canonico
    • Inserm U780
  • Rudolf Kaaks
    • Division of Clinical EpidemiologyGerman Cancer Research Centre
  • Jakob Linseisen
    • Division of Clinical EpidemiologyGerman Cancer Research Centre
  • Heiner Boeing
    • Department of EpidemiologyGerman Institute of Human Nutrition
  • Tobias Pischon
    • Department of EpidemiologyGerman Institute of Human Nutrition
  • Cornelia Weikert
    • Department of EpidemiologyGerman Institute of Human Nutrition
  • Anja Olsen
    • Institute of Cancer EpidemiologyDanish Cancer Society
  • Anne Tjønneland
    • Institute of Cancer EpidemiologyDanish Cancer Society
  • Søren Paaske Johnsen
    • Department of Clinical Epidemiology, Aalborg HospitalAarhus University Hospital
  • Majken Karoline Jensen
    • Department of Clinical Epidemiology, Aalborg HospitalAarhus University Hospital
  • Jose R. Quirós
    • Public Health and Planning Directorate
  • Carlos Alberto Gonzalez Svatetz
    • Department of Epidemiology and Cancer RegistryCatalan Institute of Oncology
  • Maria-José Sánchez Pérez
    • The Andalusian School of Public Health
  • Nerea Larrañaga
    • Public Health Department of Gipuzcoa
  • Carmen Navarro Sanchez
    • Department of EpidemiologyMurcia Health Council
  • Concepción Moreno Iribas
    • Public Health Institute of Navarra
  • Sheila Bingham
    • MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival, Department of Public Health and Primary CareUniversity of Cambridge
  • Kay-Tee Khaw
    • Clinical Gerontology Unit, Department of Public Health and Primary CareUniversity of Cambridge
  • Nick Wareham
    • MRC Epidemiology Unit
  • Timothy Key
    • Cancer Research UK Epidemiology UnitUniversity of Oxford
  • Andrew Roddam
    • Cancer Research UK Epidemiology UnitUniversity of Oxford
  • Antonia Trichopoulou
    • Department of Hygiene and EpidemiologyUniversity of Athens Medical School
  • Vassiliki Benetou
    • Department of Hygiene and EpidemiologyUniversity of Athens Medical School
  • Dimitrios Trichopoulos
    • Department of Hygiene and EpidemiologyUniversity of Athens Medical School
  • Giovanna Masala
    • Molecular and Nutritional Epidemiology Unit, CSPOScientific Institute of Tuscany
  • Sabina Sieri
    • Nutritional Epidemiology UnitItalian National Cancer Institute
  • Rosario Tumino
    • Cancer RegistryAzienda Ospedaliera “Civile M.P. Arezzo”
  • Carlotta Sacerdote
    • Department of Biomedical Science and Human OncologyCPO-Piemonte
  • Amalia Mattiello
    • Department of Clinical and Experimental MedicineFederico II University
  • W. M. Monique Verschuren
    • Centre for Prevention and health Services ResearchNational Institute for Public Health and the Environment
  • H. Bas Bueno-de-Mesquita
    • Centre for Nutrition and HealthNational Institute for Public Health and the Environment
  • Diederick E. Grobbee
    • Julius Centre for Health Sciences and Primary careUniversity Medical Centre Utrecht
  • Yvonne T. van der Schouw
    • Julius Centre for Health Sciences and Primary careUniversity Medical Centre Utrecht
  • Olle Melander
    • Department of Clinical Sciences, MalmöUniversity of Lund
  • Göran Hallmans
    • Department of Public Health and Clinical Medicine, Nutrition ResearchUmeå University
  • Patrik Wennberg
    • Department of MedicineSkellefteå Hospital
  • Eiliv Lund
    • Institute of Community MedicineUniversity of Tromsø
  • Merethe Kumle
    • Institute of Community MedicineUniversity of Tromsø
  • Guri Skeie
    • Institute of Community MedicineUniversity of Tromsø
  • Pietro Ferrari
    • International Agency for Research on Cancer — WHO
  • Nadia Slimani
    • International Agency for Research on Cancer — WHO
  • Teresa Norat
    • Department of Epidemiology and Public HealthImperial College London
  • Elio Riboli
    • Department of Epidemiology and Public HealthImperial College London
New Study

DOI: 10.1007/s10654-006-9096-8

Cite this article as:
Danesh, J., Saracci, R., Berglund, G. et al. Eur J Epidemiol (2007) 22: 129. doi:10.1007/s10654-006-9096-8

Abstract

EPIC-Heart is the cardiovascular component of the European Prospective Investigation into Cancer and Nutrition (EPIC), a multi-centre prospective cohort study investigating the relationship between nutrition and major chronic disease outcomes. Its objective is to advance understanding about the separate and combined influences of lifestyle (especially dietary), environmental, metabolic and genetic factors in the development of cardiovascular diseases by making best possible use of the unusually informative database and biological samples in EPIC. Between 1992 and 2000, 519,978 participants (366,521 women and 153,457 men, mostly aged 35–70 years) in 23 centres in 10 European countries commenced follow-up for cause-specific mortality, cancer incidence and major cardiovascular morbidity. Dietary information was collected with quantitative questionnaires or semi-quantitative food frequency questionnaires, including a 24-h dietary recall sub-study to help calibrate the dietary measurements. Information was collected on physical activity, tobacco smoking, alcohol consumption, occupational history, socio-economic status, and history of previous illnesses. Anthropometric measurements and blood pressure recordings were made in the majority of participants. Blood samples were taken from 385,747 individuals, from which plasma, serum, red cells, and buffy coat fractions were separated and aliquoted for long-term storage. By 2004, an estimated 10,000 incident fatal and non-fatal coronary and stroke events had been recorded. The first cycle of EPIC-Heart analyses will assess associations of coronary mortality with several prominent dietary hypotheses and with established cardiovascular risk factors. Subsequent analyses will extend this approach to non-fatal cardiovascular outcomes␣and to further dietary, biochemical and genetic factors.

Keywords

DietEPIC HeartProspective studyStudy protocol
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Copyright information

© Springer Science+Business Media B.V. 2007