European Journal of Epidemiology

, Volume 20, Issue 12, pp 1003–1005

Paternal Age and Epilepsy in the Offspring

Authors

    • The Danish Epidemiology Science Centre, Institute of Public Health, Department of EpidemiologyUniversity of Aarhus
  • Alissa Mork
    • The Danish Epidemiology Science Centre, Institute of Public Health, Department of EpidemiologyUniversity of Aarhus
    • Division of Environmental and Occupational HealthUniversity of Minnesota School of Public Health
  • Kreesten M. Madsen
    • The Danish Epidemiology Science Centre, Institute of Public Health, Department of EpidemiologyUniversity of Aarhus
  • Jørn Olsen
    • The Danish Epidemiology Science Centre, Institute of Public Health, Department of EpidemiologyUniversity of Aarhus
    • Department of EpidemiologyUCLA School of Public Health
Neurological Diseases

DOI: 10.1007/s10654-005-4250-2

Cite this article as:
Vestergaard, M., Mork, A., Madsen, K.M. et al. Eur J Epidemiol (2005) 20: 1003. doi:10.1007/s10654-005-4250-2

Abstract

Advanced paternal age is associated with a higher rate of de novo mutation in sperm cells and mental disorders in the offspring. In a population based cohort study of 96,654 children, we found that fathers aged 35 years or more were slightly more likely to have a child diagnosed with epilepsy compared to fathers aged 25–29 years. Our data suggest a modest paternal effect on the aetiology of epilepsy.

Keywords

de novo mutationsepidemiologyepilepsypaternal age

Copyright information

© Springer 2005