Neurological Diseases

European Journal of Epidemiology

, Volume 20, Issue 12, pp 1003-1005

First online:

Paternal Age and Epilepsy in the Offspring

  • Mogens VestergaardAffiliated withThe Danish Epidemiology Science Centre, Institute of Public Health, Department of Epidemiology, University of Aarhus Email author 
  • , Alissa MorkAffiliated withThe Danish Epidemiology Science Centre, Institute of Public Health, Department of Epidemiology, University of AarhusDivision of Environmental and Occupational Health, University of Minnesota School of Public Health
  • , Kreesten M. MadsenAffiliated withThe Danish Epidemiology Science Centre, Institute of Public Health, Department of Epidemiology, University of Aarhus
  • , Jørn OlsenAffiliated withThe Danish Epidemiology Science Centre, Institute of Public Health, Department of Epidemiology, University of AarhusDepartment of Epidemiology, UCLA School of Public Health

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Abstract

Advanced paternal age is associated with a higher rate of de novo mutation in sperm cells and mental disorders in the offspring. In a population based cohort study of 96,654 children, we found that fathers aged 35 years or more were slightly more likely to have a child diagnosed with epilepsy compared to fathers aged 25–29 years. Our data suggest a modest paternal effect on the aetiology of epilepsy.

Keywords

de novo mutations epidemiology epilepsy paternal age