European Journal of Epidemiology

, Volume 20, Issue 1, pp 67–71

Effect modification by vitamin C on the relation between gastric cancer and Helicobacter pylori

Authors

  • Dae-Sung Kim
    • Department of Preventive MedicineSeoul National University College of Medicine
  • Moo-Song Lee
    • Department of Preventive MedicineUlsan University College of Medicine
  • Young-Sik Kim
    • Department of Family MedicineUlsan University College of Medicine
  • Dong-Hyun Kim
    • Department of Social MedicineHallym University College of Medicine
  • Jong-Myon Bae
    • Department of Preventive MedicineCheju National University College of Medicine
  • Myong-Hee Shin
    • Department of Preventive MedicineSungkyunkwan University College of Medicine
    • Department of Preventive MedicineSeoul National University College of Medicine
Cancer Epidemiology

DOI: 10.1007/s10654-004-1027-y

Cite this article as:
Kim, D., Lee, M., Kim, Y. et al. Eur J Epidemiol (2005) 20: 67. doi:10.1007/s10654-004-1027-y

Abstract

A hospital-based case–control study of 295 cases with histologically confirmed gastric cancer and age and sex-matched controls was conducted to evaluate the effect of dietary vitamin C intake upon the relation between Helicobacter pylori infection and gastric cancer in Korea in 1997–1998. Anti-H. pylori IgG was detected by ELISA. A food frequency questionnaire, and a questionnaire on demographic factors, including past medical history, smoking, alcohol consumption, and life style was also administered. The prevalences of H. pylori IgG in cases and controls were 80.7% and 71.2%, respectively, and the odds ratio (OR) of H. pylori for gastric cancer was 1.68 (95% confidence interval (CI): 1.14, 2.44), after adjusting for age, sex, educational level, and a past medical history of gastritis or gastric ulcer. In a stratified analysis, H. pylori seropositivity was found to be a significant risk factor for gastric cancer in the low vitamin C intake group (OR=4.68; 95% CI: 1.97, 11.1), but not in the high vitamin C intake group (OR=0.72; 95% CI: 0.32, 1.65). Vitamin C intake was found to modify the relation between H. pylori and gastric cancer.

Keywords

CI =confidence interval; H. pylori=Helicobacter pylori; OR=odds ratio

Copyright information

© Springer 2005