Original Paper

Environmental Geochemistry and Health

, Volume 31, Supplement 1, pp 167-177

First online:

Principles and application of an in vivo swine assay for the determination of arsenic bioavailability in contaminated matrices

  • Matthew ReesAffiliated withInstitute for Medical and Veterinary Science Email author 
  • , Lloyd SansomAffiliated withSansom Institute, School of Pharmacy and Medical Sciences, Division of Health Science, University of South Australia
  • , Allan RofeAffiliated withInstitute for Medical and Veterinary Science
  • , Albert L. JuhaszAffiliated withCentre for Environmental Risk Assessment and Remediation, Division of Information Technology, Engineering and the Environment, University of South Australia
  • , Euan SmithAffiliated withCentre for Environmental Risk Assessment and Remediation, Division of Information Technology, Engineering and the Environment, University of South Australia
  • , John WeberAffiliated withCentre for Environmental Risk Assessment and Remediation, Division of Information Technology, Engineering and the Environment, University of South Australia
  • , Ravi NaiduAffiliated withCentre for Environmental Risk Assessment and Remediation, Division of Information Technology, Engineering and the Environment, University of South AustraliaCooperative Research Centre for Contamination Assessment and Remediation of the Environment
  • , Tim KuchelAffiliated withInstitute for Medical and Veterinary Science

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Abstract

The assessment of arsenic (As) bioavailability from contaminated matrices is a crucial parameter for reducing the uncertainty when estimating exposure for human health risk assessment. In vivo assessment of As utilising swine is considered an appropriate model for human health risk assessment applications as swine are remarkably similar to humans in terms of physiology and As metabolism. While limited in vivo As bioavailability data is available in the literature, few details have been provided regarding technical considerations for performing in vivo assays. This paper describes, with examples, surgical, experimental design and analytical issues associated with performing chronic and acute in vivo swine assays to determine As bioavailability in contaminated soil and food.

Keywords

Arsenic Bioavailability In vivo Swine