Environmental Geochemistry and Health

, Volume 31, Supplement 1, pp 167–177

Principles and application of an in vivo swine assay for the determination of arsenic bioavailability in contaminated matrices

Authors

    • Institute for Medical and Veterinary Science
  • Lloyd Sansom
    • Sansom Institute, School of Pharmacy and Medical Sciences, Division of Health ScienceUniversity of South Australia
  • Allan Rofe
    • Institute for Medical and Veterinary Science
  • Albert L. Juhasz
    • Centre for Environmental Risk Assessment and Remediation, Division of Information Technology, Engineering and the EnvironmentUniversity of South Australia
  • Euan Smith
    • Centre for Environmental Risk Assessment and Remediation, Division of Information Technology, Engineering and the EnvironmentUniversity of South Australia
  • John Weber
    • Centre for Environmental Risk Assessment and Remediation, Division of Information Technology, Engineering and the EnvironmentUniversity of South Australia
  • Ravi Naidu
    • Centre for Environmental Risk Assessment and Remediation, Division of Information Technology, Engineering and the EnvironmentUniversity of South Australia
    • Cooperative Research Centre for Contamination Assessment and Remediation of the Environment
  • Tim Kuchel
    • Institute for Medical and Veterinary Science
Original Paper

DOI: 10.1007/s10653-008-9237-y

Cite this article as:
Rees, M., Sansom, L., Rofe, A. et al. Environ Geochem Health (2009) 31: 167. doi:10.1007/s10653-008-9237-y

Abstract

The assessment of arsenic (As) bioavailability from contaminated matrices is a crucial parameter for reducing the uncertainty when estimating exposure for human health risk assessment. In vivo assessment of As utilising swine is considered an appropriate model for human health risk assessment applications as swine are remarkably similar to humans in terms of physiology and As metabolism. While limited in vivo As bioavailability data is available in the literature, few details have been provided regarding technical considerations for performing in vivo assays. This paper describes, with examples, surgical, experimental design and analytical issues associated with performing chronic and acute in vivo swine assays to determine As bioavailability in contaminated soil and food.

Keywords

ArsenicBioavailabilityIn vivoSwine

Copyright information

© Springer Science+Business Media B.V. 2008