Environmental and Ecological Statistics

, Volume 16, Issue 1, pp 63–73

Bootstrap methods for simultaneous benchmark analysis with quantal response data

  • R. Webster West
  • Daniela K. Nitcheva
  • Walter W. Piegorsch
Article

DOI: 10.1007/s10651-007-0073-5

Cite this article as:
West, R.W., Nitcheva, D.K. & Piegorsch, W.W. Environ Ecol Stat (2009) 16: 63. doi:10.1007/s10651-007-0073-5

Abstract

A primary objective in quantitative risk assessment is the characterization of risk which is defined to be the likelihood of an adverse effect caused by an environmental toxin or chemcial agent. In modern risk-benchmark analysis, attention centers on the “benchmark dose” at which a fixed benchmark level of risk is achieved, with a lower confidence limits on this dose being of primary interest. In practice, a range of benchmark risks may be under study, so that the individual lower confidence limits on benchmark dose must be corrected for simultaneity in order to maintain a specified overall level of confidence. For the case of quantal data, simultaneous methods have been constructed that appeal to the large sample normality of parameter estimates. The suitability of these methods for use with small sample sizes will be considered. A new bootstrap technique is proposed as an alternative to the large sample methodology. This technique is evaluated via a simulation study and examples from environmental toxicology.

Keywords

Benchmark doseBootstrapMultistage modelQuantal dataQuantitative risk assessmentSimultaneous inferences

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • R. Webster West
    • 1
  • Daniela K. Nitcheva
    • 2
  • Walter W. Piegorsch
    • 3
  1. 1.Department of StatisticsTexas A&M UniversityCollege StationUSA
  2. 2.Division of BiostatisticsSouth Carolina Department of Health and Environmental ControlColumbiaUSA
  3. 3.Department of Mathematics and BIO5 InstituteUniversity of ArizonaTucsonUSA