Bootstrap methods for simultaneous benchmark analysis with quantal response data
First Online: 28 February 2008 Received: 01 May 2005 Revised: 01 September 2006 DOI:
Cite this article as: West, R.W., Nitcheva, D.K. & Piegorsch, W.W. Environ Ecol Stat (2009) 16: 63. doi:10.1007/s10651-007-0073-5 Abstract
A primary objective in quantitative risk assessment is the characterization of risk which is defined to be the likelihood of an adverse effect caused by an environmental toxin or chemcial agent. In modern risk-benchmark analysis, attention centers on the “benchmark dose” at which a fixed benchmark level of risk is achieved, with a lower confidence limits on this dose being of primary interest. In practice, a range of benchmark risks may be under study, so that the individual lower confidence limits on benchmark dose must be corrected for simultaneity in order to maintain a specified overall level of confidence. For the case of quantal data, simultaneous methods have been constructed that appeal to the large sample normality of parameter estimates. The suitability of these methods for use with small sample sizes will be considered. A new bootstrap technique is proposed as an alternative to the large sample methodology. This technique is evaluated via a simulation study and examples from environmental toxicology.
Keywords Benchmark dose Bootstrap Multistage model Quantal data Quantitative risk assessment Simultaneous inferences References
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