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Bioaccumulation of BDE-47 and effects on molecular biomarkers acetylcholinesterase, glutathione-S-transferase and glutathione peroxidase in Mytilus galloprovincialis mussels

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Abstract

Mussels, Mytilus galloprovincialis, showed a high bioaccumulation ability when exposed to waterborne tetrabromodiphenyl ether (BDE-47), with a bioconcentration factor of 10,900 L Kg−1 wet weight, and slow depuration rates in clean seawater. Kinetic and concentration–response experiments were performed measuring in the exposed mussel the activities of three molecular biomarkers: glutathione S-transferase (GST), glutathione peroxidase (GPx) and acetylcholinesterase (AChE). The long term (30 days) exposure of mussels to all concentrations (2–15 µg L−1) of BDE-47 significantly inhibited the AChE and GST activities, a result that supports the suitability of these biomarkers in marine pollution monitoring programs. However, GPx activity showed a less consistent pattern of response depending on the concentration and the duration of exposure.

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Acknowledgments

Authors are grateful to Marta Miñambres, Tania Tato, Cristina García-Arboleya and Diego Rial for their technical assistance and personnel at ECIMAT. This work was financed by the Spanish Ministry of Science and Innovation through the Research Project (CTM2009-10908). The first author was granted with a FPU fellowship from the Spanish Government.

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The authors declare that they have no conflict of interest.

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Correspondence to Leticia Vidal-Liñán.

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Vidal-Liñán, L., Bellas, J., Fumega, J. et al. Bioaccumulation of BDE-47 and effects on molecular biomarkers acetylcholinesterase, glutathione-S-transferase and glutathione peroxidase in Mytilus galloprovincialis mussels. Ecotoxicology 24, 292–300 (2015). https://doi.org/10.1007/s10646-014-1377-5

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