Cribrostatin 6 induces death in cancer cells through a reactive oxygen species (ROS)-mediated mechanism
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- Hoyt, M.T., Palchaudhuri, R. & Hergenrother, P.J. Invest New Drugs (2011) 29: 562. doi:10.1007/s10637-010-9390-x
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Cribrostatin 6 is a quinone-containing natural product that induces the death of cancer cell lines in culture, and its mechanism of action and scope of activity are unknown. Here we show that cribrostatin 6 has broad anticancer activity, potently inducing apoptotic cell death that is not preceded by any defined cell cycle arrest. Consistent with this data, we find that cribrostatin 6 treated cells have large amounts of reactive oxygen species (ROS) and, based on transcript profiling experiments and other data, this ROS generation is likely the primary mechanism by which cribrostatin 6 induces apoptosis. Given the success of certain ROS producers as anticancer agents, cribrostatin 6 has potential as a novel chemotherapeutic agent.