Documenta Ophthalmologica

, Volume 114, Issue 1, pp 37–44

Intravitreal use of bevacizumab (Avastin) for choroidal neovascularization due to ARMD: a preliminary multifocal-ERG and OCT study

Multifocal-ERG after use of bevacizumab in ARMD
  • Marilita M. Moschos
  • Dimitrios Brouzas
  • Michael Apostolopoulos
  • Chrysanthi Koutsandrea
  • Eleni Loukianou
  • Michael Moschos
Original Paper

DOI: 10.1007/s10633-006-9036-7

Cite this article as:
Moschos, M.M., Brouzas, D., Apostolopoulos, M. et al. Doc Ophthalmol (2007) 114: 37. doi:10.1007/s10633-006-9036-7

Abstract

Purpose

To evaluate by MFERG and OCT the macular function before and after intravitreal use of bevacizumab (Avastin) in eyes suffering from CNV due to ARMD.

Methods

Eighteen eyes with subfoveal CNV due to ARMD were studied before and after intravitreal use of bevacizumab with MFERG and OCT. The post treatment follow up was three months.

Results

Before treatment, OCT shows an increase of the retinal thickening of the fovea and the electrical response densities in the fovea and parafovea were decreased in all patients. Three months after treatment, OCT showed a real resolution of the subretinal fluid. The electrical responses in the fovea and parafovea remained the same or slightly improved in some cases. The intraocular pressure remained normal and no inflammation was observed.

Conclusion

The intravitreal use of bevacizumab may provide anatomical correlates that support the concept of disease amelioration but the functional improvement of the macula three months after treatment is not obvious. However the method is promising and needs further evaluation.

Keywords

Age related macular degeneration (ARMD)Bevacizumab (Avastin)Choroidal neovascularization (CNV)Multifocal Electroretinogram (MFERG)Optical Coherence Tomography (OCT)

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • Marilita M. Moschos
    • 1
    • 2
  • Dimitrios Brouzas
    • 1
  • Michael Apostolopoulos
    • 1
  • Chrysanthi Koutsandrea
    • 1
  • Eleni Loukianou
    • 1
  • Michael Moschos
    • 1
  1. 1.Department of OphthalmologyUniversity of AthensAthensGreece
  2. 2.PiraeusGreece