Documenta Ophthalmologica

, Volume 109, Issue 2, pp 157–161

The effect of contrast reduction on pattern-reversal VEPs in suspected multiple sclerosis and optic neuritis

  • Adrian W. Davidson
  • Richard F. Scott
  • Keith W. Mitchell
Article

DOI: 10.1007/s10633-004-3831-9

Cite this article as:
Davidson, A.W., Scott, R.F. & Mitchell, K.W. Doc Ophthalmol (2004) 109: 157. doi:10.1007/s10633-004-3831-9

Abstract

A retrospective study was conducted to investigate whether the use of low-contrast stimuli in addition to the standard high-contrast stimuli would increase the sensitivity of the pattern-reversal P100 when testing for multiple sclerosis (MS) and optic neuritis (ON). We found that there was a statistically significant increase in the number of abnormal results when using 25′ checks, but not for 50′ checks. Examination of patient records showed that VEP abnormalities to low-contrast stimuli only was not prognostic for subsequent development of multiple sclerosis.

Keywords

contrastmultiple sclerosis (MS)optic neuritis (ON)sensitivityVEP

Copyright information

© Springer 2005

Authors and Affiliations

  • Adrian W. Davidson
    • 1
  • Richard F. Scott
    • 2
  • Keith W. Mitchell
    • 1
  1. 1.Regional Medical Physics DepartmentRoyal Victoria InfirmaryNewcastle Upon TyneUK
  2. 2.The University of Newcastle Upon TyneUK