The effect of contrast reduction on pattern-reversal VEPs in suspected multiple sclerosis and optic neuritis Article First Online: 17 March 2005 Accepted: 14 September 2004 DOI:
Cite this article as: Davidson, A.W., Scott, R.F. & Mitchell, K.W. Doc Ophthalmol (2004) 109: 157. doi:10.1007/s10633-004-3831-9 Abstract
A retrospective study was conducted to investigate whether the use of low-contrast stimuli in addition to the standard high-contrast stimuli would increase the sensitivity of the pattern-reversal P100 when testing for multiple sclerosis (MS) and optic neuritis (ON). We found that there was a statistically significant increase in the number of abnormal results when using 25′ checks, but not for 50′ checks. Examination of patient records showed that VEP abnormalities to low-contrast stimuli only was not prognostic for subsequent development of multiple sclerosis.
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