Digestive Diseases and Sciences

, Volume 59, Issue 6, pp 1099–1107

microRNA: A Promising Diagnostic Biomarker and Therapeutic Target for Hepatocellular Carcinoma

  • Xiaofei Li
  • Wenjun Yang
  • Lianqing Lou
  • Yongxin Chen
  • Shuang Wu
  • Guoqiang Ding
Review

DOI: 10.1007/s10620-013-3006-1

Cite this article as:
Li, X., Yang, W., Lou, L. et al. Dig Dis Sci (2014) 59: 1099. doi:10.1007/s10620-013-3006-1

Abstract

microRNAs constitute a novel class of small, non-coding RNAs that negatively regulate gene expression via translational inhibition or mRNA degradation. Aberrant miRNA expression has been implicated in the initiation, progression, and metastasis of hepatocellular carcinoma (HCC). It is well-documented that miRNAs function as either tumor suppressor genes or oncogenes in the development and progression of HCC. Additionally, substantial evidence suggests that unique miRNA signatures can serve as valuable diagnostic and prognostic biomarkers for HCC. Interestingly, certain subsets of miRNAs have also been identified as potential therapeutic targets for HCC.

Keywords

miRNAsDiagnostic markersPrognostic markersHepatocellular carcinoma

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Xiaofei Li
    • 1
  • Wenjun Yang
    • 2
    • 3
  • Lianqing Lou
    • 1
  • Yongxin Chen
    • 1
  • Shuang Wu
    • 1
  • Guoqiang Ding
    • 1
  1. 1.Department of Infectious DiseasesYiWu Central HospitalZhejiangChina
  2. 2.Department of Pharmacy, Binjiang Hospital of the Second Affiliated HospitalZhejiang University School of MedicineZhejiangChina
  3. 3.Department of PharmacyBinjiang Hospital of HangzhouHangzhouChina