Digestive Diseases and Sciences

, Volume 59, Issue 7, pp 1560–1566

Incidence and Predictors of Adenocarcinoma Following Endoscopic Ablation of Barrett’s Esophagus

  • Kazuhiro Yasuda
  • Sung Eun Choi
  • Norman S. Nishioka
  • David W. Rattner
  • William P. Puricelli
  • Angela C. Tramontano
  • Seigo Kitano
  • Chin Hur
Original Article

DOI: 10.1007/s10620-013-3002-5

Cite this article as:
Yasuda, K., Choi, S.E., Nishioka, N.S. et al. Dig Dis Sci (2014) 59: 1560. doi:10.1007/s10620-013-3002-5

Abstract

Background

The rate and risk factors of recurrent or metachronous adenocarcinoma following endoscopic ablation therapy in patients with Barrett’s esophagus (BE) have not been specifically reported.

Aim

The aim of this study was to determine the incidence and predictors of adenocarcinoma after ablation therapy for BE high-grade dysplasia (HGD) or intramucosal carcinoma (IMC).

Methods

This is a single center, retrospective review of prospectively collected data on consecutive cases of endoscopic ablation for BE. A total of 223 patients with BE (HGD or IMC) were treated by ablation between 1996 and 2011. Primary outcome measures were recurrence and new development of adenocarcinoma after ablation. Recurrence was defined as the presence of adenocarcinoma following the absence of adenocarcinoma in biopsy samples from two consecutive surveillance endoscopies. Logistic regression analysis was performed to assess predictors of adenocarcinoma after ablation.

Results

One hundred and eighty-three patients were included in the final analysis, and 40 patients were excluded: 22 for palliative ablation, eight lost to follow-up, five for residual carcinoma and five for postoperative state. Median follow-up was 39 months. Recurrence or new development of adenocarcinoma was found in 20 patients (11 %) and the median time to recurrence/development of adenocarcinoma was 11.5 months. Independent predictors of recurrent or metachronous adenocarcinoma were hiatal hernia size ≥ 4 cm (odds ratio 3.649, P = 0.0233) and histology (HGD/adenocarcinoma) after first ablation (odds ratio 4.141, P = 0.0065).

Conclusions

Adenocarcinoma after endoscopic therapy for HGD or IMC in BE is associated with large hiatal hernia and histology status after initial ablation therapy.

Keywords

Barrett’s esophagusAdenocarcinomaRecurrenceAblation techniquesEndoscopy

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Kazuhiro Yasuda
    • 1
    • 4
  • Sung Eun Choi
    • 2
  • Norman S. Nishioka
    • 3
  • David W. Rattner
    • 1
  • William P. Puricelli
    • 3
  • Angela C. Tramontano
    • 2
  • Seigo Kitano
    • 5
  • Chin Hur
    • 2
    • 3
  1. 1.Division of General and Gastrointestinal SurgeryMassachusetts General HospitalBostonUSA
  2. 2.Institute for Technology AssessmentMassachusetts General HospitalBostonUSA
  3. 3.Gastrointestinal UnitMassachusetts General HospitalBostonUSA
  4. 4.Department of Gastroenterological and Pediatric Surgery, Faculty of MedicineOita UniversityOitaJapan
  5. 5.Oita UniversityOitaJapan