Digestive Diseases and Sciences

, Volume 58, Issue 12, pp 3576–3583

Efficacy of Bispectral Index Monitoring During Balanced Propofol Sedation for Colonoscopy: A Prospective, Randomized Controlled Trial

  • Yeon Hwa Yu
  • Dong Soo Han
  • Hyun Soo Kim
  • Eun Kyung Kim
  • Chang Soo Eun
  • Kyo-Sang Yoo
  • Woo Jong Shin
  • Seungho Ryu
Original Article

DOI: 10.1007/s10620-013-2833-4

Cite this article as:
Yu, Y.H., Han, D.S., Kim, H.S. et al. Dig Dis Sci (2013) 58: 3576. doi:10.1007/s10620-013-2833-4

Abstract

Background and Aims

Appropriate use of propofol is necessary, and objective monitoring of sedation with propofol may be helpful. Studies on the efficacy of bispectral index (BIS) monitoring in deep sedation have been conducted, but its efficacy in colonoscopy with moderate sedation is unknown. In this study, the efficacy of BIS monitoring during colonoscopy with moderate level sedation via balanced propofol sedation was investigated.

Methods

To determine the cut-off value of BIS before the test, an optimal BIS value was determined. Patients who were scheduled to undergo outpatient colonoscopy were prospectively randomized to either a BIS or control group. Finally, a total of 115 patients were selected for this study. The satisfaction level, the complication, and the dosage of the administered propofol were compared.

Results

The BIS values and the modified observer’s assessment of alertness/sedation scores (MOAA/S) were positively correlated (r = 0.66 and p < 0.001). The optimal cut-off value of BIS for maintaining moderate sedation was 81, and the area under the ROC curve was 0.88 (95 % CI 0.82–0.93), indicating high prediction accuracy. However, there was no difference between the BIS group and the control group in levels of satisfaction of either patients or endoscopists. In addition, there was no difference in the complication and the required dose of propofol between both groups.

Conclusions

BIS and clinical sedation scores, MOAA/S scores, showed a high level of correlation. However, no significant efficacy was observed in the BIS group who underwent outpatient colonoscopy.

Keywords

Conscious sedationPropofolBispectral index monitorColonoscopy

Supplementary material

10620_2013_2833_MOESM1_ESM.doc (36 kb)
Supplementary material 1 (DOC 35 kb)

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Yeon Hwa Yu
    • 1
  • Dong Soo Han
    • 2
    • 5
  • Hyun Soo Kim
    • 2
  • Eun Kyung Kim
    • 2
  • Chang Soo Eun
    • 2
  • Kyo-Sang Yoo
    • 2
  • Woo Jong Shin
    • 3
  • Seungho Ryu
    • 4
  1. 1.Department of Internal MedicineSeoul Metropolitan Dongbu HospitalSeoulKorea
  2. 2.Department of Internal MedicineHanyang University College of MedicineGuriKorea
  3. 3.Department of Anesthesia and Pain MedicineHanyang University College of MedicineGuriKorea
  4. 4.Department of Occupational Medicine, Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulKorea
  5. 5.Division of Gastroenterology, Department of Internal MedicineHanyang University Guri HospitalGuri-siKorea