Ultrasound Elastography for Fibrosis Surveillance Is Cost Effective in Patients with Chronic Hepatitis C Virus in the UK
- C. CanavanAffiliated withDivision of Epidemiology and Public Health, Nottingham University Email author
- , J. EisenburgAffiliated withInstitute for Technology Assessment, Massachusetts General Hospital
- , L. MengAffiliated withInstitute for Technology Assessment, Massachusetts General Hospital
- , K. CoreyAffiliated withGastrointestinal Unit, Massachusetts General Hospital
- , C. HurAffiliated withInstitute for Technology Assessment, Massachusetts General HospitalGastrointestinal Unit, Massachusetts General Hospital
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Chronic hepatitis C (HCV) is a significant risk factor for cirrhosis and subsequently hepatocellular carcinoma (HCC). HCV patients with cirrhosis are screened for HCC every 6 months. Surveillance for progression to cirrhosis and consequently access to HCC screening is not standardized. Liver biopsy, the usual test to determine cirrhosis, carries a significant risk of morbidity and associated mortality. Transient ultrasound elastography (fibroscan) is a non-invasive test for cirrhosis.
This study assesses the cost effectiveness of annual surveillance for cirrhosis in patients with chronic HCV and the effect of replacing biopsy with fibroscan to diagnose cirrhosis.
A Markov decision analytic model simulated a hypothetical cohort of 10,000 patients with chronic HCV initially without fibrosis over their lifetime. The cirrhosis surveillance strategies assessed were: no surveillance; current practice; fibroscan in current practice with biopsy to confirm cirrhosis; fibroscan completely replacing biopsy in current practice (definitive); annual biopsy; annual fibroscan with biopsy to confirm cirrhosis; annual definitive fibroscan.
Our results demonstrate that annual definitive fibroscan is the optimal strategy to diagnose cirrhosis. In our study, it diagnosed 20 % more cirrhosis cases than the current strategy, with 549 extra patients per 10,000 accessing screening over a lifetime and, consequently, 76 additional HCC cases diagnosed. The lifetime cost is £98.78 extra per patient compared to the current strategy for 1.72 additional unadjusted life years. Annual fibroscan surveillance of 132 patients results in the diagnosis one additional HCC case over a lifetime. The incremental cost-effectiveness ratio for an annual definitive fibroscan is £6,557.06/quality-adjusted life years gained.
Annual definitive fibroscan may be a cost-effective surveillance strategy to identify cirrhosis in patients with chronic HCV, thereby allowing access of these patients to HCC screening.
KeywordsHepatitis C Liver fibrosis Hepatocellular carcinoma Screening Health economics Outcomes research Radiology/imaging
- Ultrasound Elastography for Fibrosis Surveillance Is Cost Effective in Patients with Chronic Hepatitis C Virus in the UK
Digestive Diseases and Sciences
Volume 58, Issue 9 , pp 2691-2704
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
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- Hepatitis C
- Liver fibrosis
- Hepatocellular carcinoma
- Health economics
- Outcomes research
- Industry Sectors
- Author Affiliations
- 1. Division of Epidemiology and Public Health, Nottingham University, Clinical Sciences Building, City Hospital Campus, Hucknall Road, Nottingham, NG5 1PB, UK
- 2. Institute for Technology Assessment, Massachusetts General Hospital, Boston, MA, USA
- 3. Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA, USA