Digestive Diseases and Sciences

, Volume 58, Issue 6, pp 1790–1796

Thrombocytosis and Hepatocellular Carcinoma

Original Article

DOI: 10.1007/s10620-012-2527-3

Cite this article as:
Carr, B.I. & Guerra, V. Dig Dis Sci (2013) 58: 1790. doi:10.1007/s10620-012-2527-3

Abstract

Background

Thrombocytopenia has been reported to be both a risk factor for hepatocellular carcinoma (HCC) development as well as a prognostic factor. Many HCCs also occur in presence of normal platelets.

Aim

To examine a cohort of HCC patients with associated thrombocytosis.

Methods

Records were examined of a cohort of 634 biopsy-proven and randomly presenting HCC patients without thrombocytopenia.

Results

In the total cohort, 52 patients were identified with thrombocytosis (platelet levels >400 × 109/L) and compared with 582 patients with normal platelet values. The average tumor sizes were 13.1 versus 8.8 cm (p < 0.0001), and their total average bilirubin levels were 0.9 versus 1.5 (p = 0.02), comparing thrombocytosis patients versus normal platelet count HCC patients. These differences were even more pronounced in patients with HCC sizes >5 cm. Thrombocytosis patients were younger and had less cirrhosis, but similar percent with hepatitis B or C or alcohol consumption.

Conclusion

Thrombocytosis in association with HCC occurs in patients with larger tumor sizes and better liver function.

Keywords

HCCSizeThrombocytosisPortal vein thrombosis

Abbreviations

HCC

Hepatocellular carcinoma

AFP

Alpha-fetoprotein

PVT

Portal vein thrombosis

Hgb

Hemoglobin

Plts

Platelets

WBC

White blood count

GGTP

Gamma glutamyltranspeptidase

PT

Prothrombin time

M

Mean

SD

Standard deviation

CAT

Computerized axial tomography

K

× 103

Platelet units

× 109/L

Bilirubin values

mg/dL

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Nutritional CarcinogenesisIRCCS “S. de Bellis”, National Institute for Digestive DiseasesCastellana GrotteItaly
  2. 2.Department of EpidemiologyIRCCS “S. de Bellis”, National Institute for Digestive DiseasesCastellana GrotteItaly