, Volume 58, Issue 1, pp 20-22,
Open Access This content is freely available online to anyone, anywhere at any time.
Date: 27 Oct 2012

The Role of Steatosis in HBsAg Seroclearance for Patients with Chronic Hepatitis B Infection: Fact or Fiction?

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In the Asia Pacific region, chronic hepatitis B (CHB) is an endemic infection, and is the most important cause of cirrhosis and hepatocellular carcinoma (HCC). The understanding of the natural history of CHB through large longitudinal population studies has been pivotal in identifying risk factors which are important for disease progression [1, 2]. Well-established risk factors include host factors, such as age and gender, and viral factors, such as genotype and viral load. The interplay between other types of liver diseases and CHB is less well studied. Non-alcoholic fatty liver disease (NAFLD), an entity which has traditionally been associated with Western populations, is now becoming more prevalent in many parts of Asia. This is partly due to the rising prevalence of obesity in the Asia Pacific countries. Therefore, it is unavoidable that there will be an increasing trend of NAFLD co-existing with other liver diseases. The effects of NAFLD on viral hepatitis have been described main ...