Liver–Intestine-Cadherin Is a Sensitive Marker of Intestinal Differentiation During Barrett’s Carcinogenesis
- Anna MokrowieckaAffiliated withDepartment of Digestive Tract Diseases, Medical University of Lodz Email author
- , Sarah ZonnurAffiliated withInstitute of Pathology, Klinikum Bayreuth
- , Lothar VeitsAffiliated withInstitute of Pathology, Klinikum Bayreuth
- , Jacek MusialAffiliated withDepartment of Pathology, Chair of Oncology, Medical University of Lodz
- , Radzislaw KordekAffiliated withDepartment of Pathology, Chair of Oncology, Medical University of Lodz
- , Mariusz LochowskiAffiliated withDepartment of Chest Surgery and Respiratory Rehabilitation, Medical University of Lodz
- , Jozef KozakAffiliated withDepartment of Chest Surgery and Respiratory Rehabilitation, Medical University of Lodz
- , Ewa Malecka-PanasAffiliated withDepartment of Digestive Tract Diseases, Medical University of Lodz
- , Michael ViethAffiliated withInstitute of Pathology, Klinikum Bayreuth
- and 1 more
- , Arndt HartmannAffiliated withInstitute of Pathology, University of Erlangen-Nurnberg
- Show less
Histopathologic differentiation between the stages of Barrett’s carcinogenesis is often challenging. Liver–intestine (LI)-cadherin, an intestine-specific marker, is involved in intestinal metaplasia development in gastric and colon cancers and could be of value in diagnosis and differentiation.
To examine the expression of LI-cadherin in the sequence of Barrett’s carcinogenesis and to evaluate its association with clinicopathological data.
LI-cadherin expression was immunohistologically investigated, by use of anti-CDH17 antibody, in gastric mucosa (GM) biopsies taken from the cardia (n = 9), in Barrett’s esophagus (BE) without intraepithelial neoplasia (without IEN) (n = 9) and BE with low-grade IEN (n = 11), and in esophageal adenocarcinoma (ADC) (n = 13).
The immunoreactivity score was highest in adenocarcinoma (mean IRS = 4.0), and dropped gradually from BE with IEN and BE without IEN (mean IRS = 2.0) to cardia mucosa (IRS = 0). Similarly, the intensity of staining and the percentage of positive cells increased during the sequential stages of BE carcinogenesis. Comparative analysis showed that LI-cadherin expression was significantly different between cardiac epithelium and ADC. Also, percentage of positive cells in GM was significantly different from that in BE with IEN. LI-cadherin IRS was lower for tumors with poor differentiation than for moderately differentiated tumors, but the difference was not statistically significant.
LI-cadherin is a sensitive marker of intestinal metaplasia and can be helpful for early histologic diagnosis of Barrett’s esophagus; it is, however, not significantly different between BE with and without IEN, and cannot be used to distinguish between these.
KeywordsLI-cadherin Barrett’s esophagus Esophageal adenocarcinoma Intestinal metaplasia Intraepithelial neoplasia
- Liver–Intestine-Cadherin Is a Sensitive Marker of Intestinal Differentiation During Barrett’s Carcinogenesis
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Digestive Diseases and Sciences
Volume 58, Issue 3 , pp 699-705
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Barrett’s esophagus
- Esophageal adenocarcinoma
- Intestinal metaplasia
- Intraepithelial neoplasia
- Industry Sectors
- Author Affiliations
- 1. Department of Digestive Tract Diseases, Medical University of Lodz, Str. Kopcinskiego 22, 90-153, Lodz, Poland
- 2. Institute of Pathology, Klinikum Bayreuth, Preuschwitzer Str. 101, 95445, Bayreuth, Germany
- 3. Department of Pathology, Chair of Oncology, Medical University of Lodz, Str. Pomorska 251, 92-213, Lodz, Poland
- 4. Department of Chest Surgery and Respiratory Rehabilitation, Medical University of Lodz, Str. Pabianicka 62, 93-513, Lodz, Poland
- 5. Institute of Pathology, University of Erlangen-Nurnberg, Krankenhausstraße 8-10, Erlangen, Germany