Menarche in Pediatric Patients with Crohn’s Disease
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Background and Aims
The timing of menarche in Crohn’s disease (CD) is poorly described. Our objectives were to study age at menarche onset in CD, and factors associated with this.
Mean chronological age (CA) of CD patients (15.6 years) did not differ from that of the NHANES cohort (15.7 years; P = 0.91). The median CA at menarche (13.9 years) in CD was older than in the NHANES sample (12.0 years) (P < 0.00005). In CD patients, the cumulative incidence of menarche was 10 % at CA 12 years, 51 % at CA 14 years, and 100 % at CA 16 years. Sixty-eight percent reached menarche by bone age (BA) 13.5 years and 100 % by BA greater than 14.0 years. Menarche occurred earliest in South Asians, followed by East Asians, and then Caucasians (P = 0.02).
CA at menarche is delayed in CD compared with the NHANES cohort. BA at menarche in CD is similar to BA at menarche reported for healthy children. CA at menarche in CD differs by race. If menarche has not occurred by BA greater than 14.0 years, endocrinology referral should be considered.
- Rosen DS. Pubertal growth and sexual maturation for adolescents with chronic illness or disability. Pediatrician. 1991;18:105–120.
- Beattie RM. Symposium 6: Young people, artificial nutrition and transitional care: nutrition, growth and puberty in children and adolescents with Crohn’s disease. Proc Nutr Soc. 2010;69:174–177. CrossRef
- Brain CE, Savage MO. Growth and puberty in chronic inflammatory bowel disease. Bailleres Clin Gastroenterol. 1994;8:83–100. CrossRef
- Simon D. Puberty in chronically diseased patients. Horm Res. 2002;57:53–56. CrossRef
- Pozo J, Argente J. Delayed puberty in chronic illness. Best Pract Res Clin Endocrinol Metab. 2002;16:73–90. CrossRef
- Gupta N, Lustig R, Kohn M, et al. Sex differences in growth impairment in pediatric patients with Crohn’s disease: role of IGF-1. Inflamm Bowel Dis. 2011;17(11):2318–2325. CrossRef
- Smith DW. Growth and Its Disorders. Philadelphia: Saunders 1977;15:6.
- Morris NM, Udry JR. Validation of a self-administered instrument to assess stage of adolescent development. J Youth Adolesc. 1980;9:271–280. CrossRef
- Greulich WW, Pyle SI. Radiographic atlas of skeletal development of the hand and wrist. 2nd ed. Stanford, CA: Stanford University Press; 1959.
- Ayer M, Brunk HD, Ewing GM, et al. An empirical distribution function for sampling with incomplete information. Ann Math Stat. 1995;26:641–647. CrossRef
- Centers for Disease Control and Prevention (CDC). National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Data. Hyattsville, MD: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, [2007–2008] [http://www.cdc.gov/nchs/nhanes/nhanes2007-2008/nhanes07_08.htm].
- Chumlea WC, Schubert CM, Roche AF, et al. Age at menarche and racial comparisons in US girls. Pediatrics. 2003;111:110–113. CrossRef
- Onat T, Bilsel E. Age at menarche: relationships to socioeconomic status, growth rate in stature and weight, and skeletal and sexual maturation. Am J Human Biol. 1995;7:741–750. CrossRef
- Simmons K, Greulich WW. Menarcheal age and the height, weight and skeletal age of girls age 7 to 17 years. J Pediatr. 1943;22:518–548. CrossRef
- Canavese F, Charles YP, Dimeglio A. Skeletal age assessment from elbow radiographs. Review of the literature. Chir Organi Mov. 2008;92:1–6. CrossRef
- Marshall WA, de Limongi Y. Skeletal maturity and the prediction of age at menarche. Ann Hum Biol. 1976;3:235–243. CrossRef
- Weber AM, Ziegler C, Belinson JL, et al. Gynecologic history of women with inflammatory bowel disease. Obstet Gynecol. 1995;86:843–847. CrossRef
- Ferguson A, Sedgwick DM. Juvenile onset inflammatory bowel disease: height and body mass index in adult life. BMJ. 1994;308:1259–1263. CrossRef
- Adams Hillard PJ. Menstruation in adolescents: what’s normal, what’s not. Ann NY Acad Sci. 2008;1135:29–35.
- Ballinger AB, Savage MO, Sanderson IR. Delayed puberty associated with inflammatory bowel disease. Pediatr Res. 2003;53:205–210. CrossRef
- Biro FM, Galvez MP, Greenspan LC, et al. Pubertal assessment method and baseline characteristics in a mixed longitudinal study of girls. Pediatrics. 2010;126:e583–e590. CrossRef
- Anderson SE, Must A. Interpreting the continued decline in the average age at menarche: results from the two nationally representative surveys of U.S. girls studied 10 years apart. J Pediatr. 2005;147:753–760. CrossRef
- Herman-Giddens ME, Slora EJ, Wasserman RC, et al. Secondary sexual characteristics and menses in young girls seen in office practice: a study from the pediatric research in office settings network. Pediatrics. 1997;99:505–512. CrossRef
- Freedman DS, Khan LK, Serdula MK, et al. Relation of age at menarche to race, time period, and anthropometric dimensions: the Bogalusa heart study. Pediatrics. 2002;110:e43. CrossRef
- Biro FM, McMahon RP, Striegel-Moore R, et al. Impact of timing of pubertal maturation on growth in black and white female adolescents: The National Heart, Lung, and Blood Institute Growth and Health Study. J Pediatr. 2001;138:636–643. CrossRef
- Anderson SE, Dallal GE, Must A. Relative weight and race influence average age at menarche: results from two nationally representative surveys of US girls studied 25 years apart. Pediatrics. 2003;111:844–850. CrossRef
- Macmahon B. Age at menarche: United States, 1973. Rockville, MD: National Center for Health Statistics; 1974 (DHEW publication [HRA] 74-1615 Series 11 no. 133).
- Adair LS, Gordon-Larsen P. Maturational timing and overweight prevalence in US adolescent girls. Am J Public Health. 2001;91:642–644. CrossRef
- Koprowski C, Ross RK, Mack WJ, Henderson BE, Bernstein L. Diet, body size and menarche in a multiethnic cohort. Br J Cancer. 1999;79:1907–1911. CrossRef
- Zacharias L, Rand WM, Wurtman RJ. A prospective study of sexual development and growth in American girls: the statistics of menarche. Obstet Gynecol Surv. 1976;31:325–337. CrossRef
- Koprowski C, Coates RJ, Bernstein L. Ability of young women to recall past body size and age at menarche. Obes Res. 2001;9:478–485. CrossRef
- Johannesson M, Gottlieb C, Hjelte L. Delayed puberty in girls with cystic fibrosis despite good clinical status. Pediatrics. 1997;99:29–34. CrossRef
- Neinstein LS, Stewart D, Wang CI, Johnson I. Menstrual dysfunction in cystic fibrosis. J Adolesc Health Care. 1983;4:153–157. CrossRef
- Umlawska W, Sands D, Zielinska A. Age of menarche in girls with cystic fibrosis. Folia Histochem Cytobiol. 2010;48:185–190. CrossRef
- Moshang T, Holsclaw DS Jr. Menarchal determinants in cystic fibrosis. Am J Dis Child. 1980;134:1139–1142.
- Mitchell-Heggs P, Mearns M, Batten JC. Cystic fibrosis in adolescents and adults. Q J Med. 1976;45:479–504.
- Stern RC, Boat TF, Doershuk CF, et al. Course of cystic fibrosis in 95 patients. J Pediatr. 1976;89:406–411. CrossRef
- Fraser PA, Hoch S, Erlandson D, et al. The timing of menarche in juvenile rheumatoid arthritis. J Adolesc Health Care. 1988;9:483–487. CrossRef
- Graham C, Maude GH, Serjeant GR. Delayed menarche in homozygous sickle cell disease. West Indian Med J. 1986;35:18–22.
- Zemel BS, Kawchak DA, Ohene-Frempong K, et al. Effects of delayed pubertal development, nutritional status, and disease severity of longitudinal patterns of growth failure in children with sickle cell disease. Pediatr Res. 2007;61:607–613. CrossRef
- Menarche in Pediatric Patients with Crohn’s Disease
Digestive Diseases and Sciences
Volume 57, Issue 11 , pp 2975-2981
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- 1. Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Francisco, 500 Parnassus Avenue, MU-407 East, Box 0136, San Francisco, CA, 94143, USA
- 2. Division of Endocrinology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA
- 3. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA