Digestive Diseases and Sciences

, Volume 57, Issue 11, pp 2975–2981

Menarche in Pediatric Patients with Crohn’s Disease

Authors

    • Division of Gastroenterology, Hepatology, and Nutrition, Department of PediatricsUniversity of California, San Francisco
  • Robert H. Lustig
    • Division of Endocrinology, Department of PediatricsUniversity of California, San Francisco
  • Michael A. Kohn
    • Department of Epidemiology and BiostatisticsUniversity of California, San Francisco
  • Eric Vittinghoff
    • Department of Epidemiology and BiostatisticsUniversity of California, San Francisco
Original Article

DOI: 10.1007/s10620-012-2235-z

Cite this article as:
Gupta, N., Lustig, R.H., Kohn, M.A. et al. Dig Dis Sci (2012) 57: 2975. doi:10.1007/s10620-012-2235-z

Abstract

Background and Aims

The timing of menarche in Crohn’s disease (CD) is poorly described. Our objectives were to study age at menarche onset in CD, and factors associated with this.

Methods

We compared the age at menarche of 34 CD patients with that for 545 controls, using data in the National Health and Nutrition Examination Survey (NHANES).

Results

Mean chronological age (CA) of CD patients (15.6 years) did not differ from that of the NHANES cohort (15.7 years; P = 0.91). The median CA at menarche (13.9 years) in CD was older than in the NHANES sample (12.0 years) (P < 0.00005). In CD patients, the cumulative incidence of menarche was 10 % at CA 12 years, 51 % at CA 14 years, and 100 % at CA 16 years. Sixty-eight percent reached menarche by bone age (BA) 13.5 years and 100 % by BA greater than 14.0 years. Menarche occurred earliest in South Asians, followed by East Asians, and then Caucasians (P = 0.02).

Conclusions

CA at menarche is delayed in CD compared with the NHANES cohort. BA at menarche in CD is similar to BA at menarche reported for healthy children. CA at menarche in CD differs by race. If menarche has not occurred by BA greater than 14.0 years, endocrinology referral should be considered.

Keywords

Inflammatory bowel diseasePubertyMensesChildrenAdolescents

Abbreviations

BA

Bone age

BA-Z

Z score based on bone age

BMI

Body mass index

CA

Chronological age

CA-Z

Z score based on chronological age

CD

Crohn’s disease

IBD

Inflammatory bowel disease

NHANES

National Health and Nutrition Examination Survey

UCSF

University of California, San Francisco

Copyright information

© Springer Science+Business Media, LLC 2012