Digestive Diseases and Sciences

, Volume 57, Issue 6, pp 1647–1651

Is Ulcerative Colitis Associated with Survival Among Older Persons with Colorectal Cancer in the US? A Population-Based Case–Control Study

  • Aasma Shaukat
  • Nadim I. Salfiti
  • Daniel J. Virnig
  • David H. Howard
  • Shanthi V. Sitaraman
  • Jonathan M. Liff
  • Frank A. Lederle
Original Article

DOI: 10.1007/s10620-011-1966-6

Cite this article as:
Shaukat, A., Salfiti, N.I., Virnig, D.J. et al. Dig Dis Sci (2012) 57: 1647. doi:10.1007/s10620-011-1966-6

Abstract

Background

While ulcerative colitis (UC) is a risk factor for colorectal cancer, the association of UC with survival after colorectal cancer has not been studied in an older population.

Aims

The objective of our study was to compare the survival of colorectal cancer between persons with and without UC.

Methods

All cases of colorectal cancer (CRC) in persons 67 and older residing in a SEER catchment area and enrolled in the Medicare between 1993 and 1999 were assessed. We identified diagnosis of UC using ICD-9 codes on Medicare outpatient, office, and inpatient claims in the 2 years prior to the date of diagnosis. We used Cox proportional hazards model and Kaplan–Meier curves to compare survival between individuals with UC and CRC (UC–CRC) and sporadic CRC

Results

We identified 47,543 cases of colorectal cancer. Cases with UC–CRC tend to be diagnosed at earlier stages compared to sporadic CRC (42 vs. 37% local (TNM stage 1 and 2) and 11 vs. 17% distant spread (TNM stage 4), respectively; P value = 0.04). Controlling for age, gender, race and stage, diagnosis of UC did not affect the 3-year survival for CRC

Conclusions

Colorectal cancers tend to be diagnosed at earlier stages among persons with UC, but there is no difference in 3-year survival rates for colorectal cancer among individuals with and without UC.

Keywords

Ulcerative colitisSurvivalSEER-MedicareColorectal cancer

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Aasma Shaukat
    • 1
  • Nadim I. Salfiti
    • 1
  • Daniel J. Virnig
    • 1
  • David H. Howard
    • 5
  • Shanthi V. Sitaraman
    • 3
  • Jonathan M. Liff
    • 4
  • Frank A. Lederle
    • 2
  1. 1.Section of Gastroenterology, VA Medical CenterUniversity of MinnesotaMinneapolisUSA
  2. 2.Department of Medicine, VA Medical CenterUniversity of MinnesotaMinneapolisUSA
  3. 3.Division of Digestive Diseases, Department of MedicineEmory UniversityAtlantaUSA
  4. 4.Department of Epidemiology, Rollins School of Public HealthEmory UniversityAtlantaUSA
  5. 5.Department of Health, Policy and Management, Rollins School of Public HealthEmory UniversityAtlantaUSA