Digestive Diseases and Sciences

, Volume 57, Issue 2, pp 568–572

Impact of Calcineurin Inhibitors on Hepatitis C Recurrence After Liver Transplantation

  • Robin D. Kim
  • Shugo Mizuno
  • John B. Sorensen
  • Jason J. Schwartz
  • Shiro Fujita
Original Article

DOI: 10.1007/s10620-011-1871-z

Cite this article as:
Kim, R.D., Mizuno, S., Sorensen, J.B. et al. Dig Dis Sci (2012) 57: 568. doi:10.1007/s10620-011-1871-z

Abstract

Background and Aims

The aim of this retrospective study is to assess the impact of calcineurin inhibitors on hepatitis C virus recurrence following liver transplantation.

Methods

A total of 396 patients underwent liver transplantation for hepatitis C virus-induced liver disease between 1991 and 2005 at a single center. We examined the pre- and post-operative characteristics of patients who received either cyclosporine (n = 126) or tacrolimus (n = 270) as maintenance immunosuppression. In addition, we compared the postoperative course, including patient, graft and hepatitis C virus recurrence-free survival between the two groups.

Results

There were no significant differences between the two groups in either post-operative hepatitis C virus—ribonucleic acid or histological fibrosis score (performed within 6 months after transplant per protocol). The graft and patient survivals did not differ between the two groups (logrank p = 0.34 and 0.15, respectively). Histologic hepatitis C virus recurrence-free survival, however, was significantly higher in the cyclosporine group than in the tacrolimus group (55.4 vs. 30.8% at 1 year, 18.6 vs. 10.3% at 3 years, 16.7 vs. 8.1% at 5 years, p < 0.001).

Conclusions

Patients transplanted for hepatitis C virus and treated with cyclosporine versus tacrolimus may have a higher recurrence-free survival.

Keywords

Calcineurin inhibitorsHepatitis C recurrenceLiver transplantation

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Robin D. Kim
    • 1
  • Shugo Mizuno
    • 2
  • John B. Sorensen
    • 1
  • Jason J. Schwartz
    • 1
  • Shiro Fujita
    • 2
  1. 1.Section of Transplantation, Department of SurgeryUniversity of Utah School of MedicineSalt Lake CityUSA
  2. 2.Department of Surgery, Division of TransplantationUniversity of Florida College of Medicine, M-125 Health Science CenterGainesvilleUSA