Digestive Diseases and Sciences

, 56:3316

Hepatocellular Carcinoma Screening Rates Vary by Etiology of Cirrhosis and Involvement of Gastrointestinal Sub-specialists

  • Vilas Patwardhan
  • Sonali Paul
  • Kathleen E. Corey
  • Sameer M. Mazhar
  • James M. Richter
  • Michael Thiim
  • Raymond T. Chung
Original Article

DOI: 10.1007/s10620-011-1836-2

Cite this article as:
Patwardhan, V., Paul, S., Corey, K.E. et al. Dig Dis Sci (2011) 56: 3316. doi:10.1007/s10620-011-1836-2

Abstract

Background

Regular screening of cirrhotic patients for hepatocellular carcinoma (HCC) has been suboptimal, but there is little data regarding specific risk factors for reduced screening.

Methods

From 1996 to 2010, patients with cirrhosis were retrospectively identified from outpatient gastroenterology and primary care practices. Data was obtained from the diagnosis of cirrhosis until the time of elevated alpha-fetoprotein (AFP) or lesion suspicious for HCC, death, liver transplantation, or end of the data collection period. Recommended screening was defined as abdominal imaging (ultrasound, contrast-enhanced CT, or MRI) with or without serum alpha-fetoprotein (AFP) at least once every 12 months based on professional guidelines.

Results

One hundred fifty-six patients with cirrhosis were identified. The etiologies of cirrhosis were viral hepatitis (n = 65), alcohol (n = 40), non-alcoholic steatohepatitis (NASH) (n = 27), and non-viral, non-alcoholic, non-NASH cirrhosis (n = 24). Of the 156 patients, 51% received recommended screening for HCC. Patients with NASH cirrhosis received recommended screening significantly less (p = 0.016) than cirrhotics with viral hepatitis, alcoholic cirrhosis, or non-viral, non-alcoholic, non-NASH cirrhosis and were less likely to receive gastroenterology referral (p < 0.001). Additionally, 20 patients were diagnosed with cirrhosis incidentally during a surgical procedure. These patients were significantly less likely to receive recommended HCC screening than those diagnosed non-surgically (10.0 vs. 56.6%; p < 0.001). Screening was significantly more likely to occur in patients seen regularly by a gastrointestinal subspecialist (66.7 vs. 22.8%; p < 0.001).

Conclusions

Patients with NASH cirrhosis and incidentally discovered cirrhosis have low rates of HCC screening and are referred less often to gastroenterologists. These data suggest a need for increased education about NASH cirrhosis and better systems of communication among general practitioners, surgeons, and gastroenterologists.

Keywords

Cirrhosis Hepatocellular carcinoma Screening Non-alcoholic steatohepatitis 

Abbreviations

HCC

Hepatocellular carcinoma

HBV

Hepatitis B virus

HCV

Hepatitis C virus

NAFLD

Non-alcoholic fatty liver disease

NASH

Non-alcoholic steatohepatitis

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Vilas Patwardhan
    • 1
  • Sonali Paul
    • 1
  • Kathleen E. Corey
    • 1
    • 2
  • Sameer M. Mazhar
    • 1
    • 2
  • James M. Richter
    • 1
    • 2
  • Michael Thiim
    • 1
    • 2
  • Raymond T. Chung
    • 1
    • 2
  1. 1.Department of MedicineMassachusetts General HospitalBostonUSA
  2. 2.Gastrointestinal UnitMassachusetts General HospitalBostonUSA

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