Digestive Diseases and Sciences

, Volume 56, Issue 8, pp 2372–2377

Fecal Calprotectin Is a Useful Marker for Disease Activity in Pediatric Patients with Inflammatory Bowel Disease


  • Tomoki Aomatsu
    • Department of PediatricsOsaka Medical College
    • Department of PediatricsOsaka Medical College
  • Kyoichi Matsumoto
    • Mikuri Immunological Lab. Co
  • Emi Kimura
    • Mikuri Immunological Lab. Co
  • Keisuke Inoue
    • Department of PediatricsOsaka Medical College
  • Akira Andoh
    • Division of Mucosal Immunology, Graduate School of MedicineShiga University of Medical Science
  • Hiroshi Tamai
    • Department of PediatricsOsaka Medical College
Original Article

DOI: 10.1007/s10620-011-1633-y

Cite this article as:
Aomatsu, T., Yoden, A., Matsumoto, K. et al. Dig Dis Sci (2011) 56: 2372. doi:10.1007/s10620-011-1633-y



Studies evaluating the correlation between endoscopic disease activity and noninvasive markers are scarce in inflammatory bowel disease (IBD).


The aim of this study is to evaluate the accuracy of the fecal calprotectin (FC) assay as a marker of disease activity of IBD, as determined by an extensive endoscopic scoring system.


Thirty-five children and adolescents with IBD [17 with ulcerative colitis (UC) and 18 with Crohn’s disease (CD)] and 28 healthy volunteers were enrolled. FC levels were determined by ELISA. The sum of Matts’ score for UC and the simple endoscopic score for Crohn’s disease (SES-CD) were used. The ileal lesions were evaluated by ultrasonography.


In UC patients, there was a strong correlation between FC levels and the sum of Matts’ score (r = 0.838, p < 0.01). FC levels were significantly elevated in endoscopically active patients (median 1,562.5 μg/g) as compared to patients in endoscopic remission (median 38.9 μg/g) or healthy controls (median 19.9 μg/g). In CD patients, there was a strong correlation between FC levels and the SES-CD score (r = 0.760, p < 0.01). The FC levels were significantly higher in endoscopically active patients (median 2,037.5 μg/g) than in endoscopically inactive patients (median 172.5 μg/g) or healthy controls (median 19.9 μg/g), respectively. The FC levels of patients with ileal wall thickening (median 2,225.0 μg/g) were significantly higher than healthy controls (median 19.9 μg/g) and patients lacking ileal wall thickening (median 17.5 μg/g), respectively.


The FC assay is a useful marker for the detection of mucosal inflammation in pediatric IBD patients.


Fecal calprotectinInflammatory bowel diseaseChildrenMucosal healingBiomarker

Copyright information

© Springer Science+Business Media, LLC 2011