Digestive Diseases and Sciences

, Volume 56, Issue 5, pp 1557–1564

Optimum Palliation of Inoperable Hilar Cholangiocarcinoma: Comparative Assessment of the Efficacy of Plastic and Self-Expanding Metal Stents

  • Ramu P. Raju
  • Sathya R. Jaganmohan
  • William A. Ross
  • Marta L. Davila
  • Milind Javle
  • Gottumukkala S. Raju
  • Jeffrey H. Lee
Original Article

DOI: 10.1007/s10620-010-1550-5

Cite this article as:
Raju, R.P., Jaganmohan, S.R., Ross, W.A. et al. Dig Dis Sci (2011) 56: 1557. doi:10.1007/s10620-010-1550-5

Abstract

Background

Endoscopic retrograde biliary drainage (ERBD) with plastic or self-expanding metal stents (SEMS) is often performed for palliative care for cholangiocarcinoma.

Objective

The objective was to compare the clinical effectiveness, including stent patency, complication rate, and need for salvage percutaneous transhepatic biliary drainage, of SEMS and plastic stents.

Methods

A total of 100 patients with inoperable cholangiocarcinoma were identified from an endoscopic database from 1/1/01 to 9/30/06 at a tertiary cancer hospital and their clinical history was retrospectively reviewed. All patients were followed to death, re-intervention, or for at least one year. Stent patency and patient survival were estimated by Kaplan–Meier analysis, supplemented by the log-rank test for comparisons between groups.

Results

Forty-eight patients had SEMS placed and 52 patients had plastic stents placed. ERBD was successful in 46 (95.8%) in the SEMS group and 49 (94.2%) in the plastic group (P = 0.67). Median patency times were 1.86 months in the plastic group and 5.56 months in the SEMS group (P < 0.0001). A mean of 1.53 and 4.60 re-interventions were performed in the SEMS and plastic groups, respectively (P < 0.05). Complications occurred in 4/48 (8.3%) in the SEMS group and 4/52 (7.7%) in the plastic group (P = 0.79). Median survival was 9.08 and 8.22 months in the SEMS and plastic stent groups, respectively (P = 0.50).

Conclusion

Metallic stent patency was superior to that of plastic stents in all Bismuth–Corlette classifications of hilar cholangiocarcinoma with similar complication rates. SEMS seem to be cost-effective and, when feasible, should be considered as an initial intervention in patients with inoperable hilar cholangiocarcinoma.

Keywords

CholangiocarinomaEndoscopic palliationBiliary stentingMalignant hilar biliary obstruction

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Ramu P. Raju
    • 1
  • Sathya R. Jaganmohan
    • 1
  • William A. Ross
    • 1
  • Marta L. Davila
    • 1
  • Milind Javle
    • 2
  • Gottumukkala S. Raju
    • 1
  • Jeffrey H. Lee
    • 1
  1. 1.Department of Gastroenterology, Hepatology, and NutritionMD Anderson Cancer CenterHoustonUSA
  2. 2.Department of Gastrointestinal Medical OncologyMD Anderson Cancer CenterHoustonUSA