Digestive Diseases and Sciences

, Volume 56, Issue 2, pp 555–563

Non-Invasive Index for Predicting Significant Liver Fibrosis: Comparison of Diagnostic Performances in Patients with Chronic Hepatitis B and C

  • Jae Youn Cheong
  • Soon Ho Um
  • Yeon Seok Seo
  • Dong Joon Kim
  • Seong Gyu Hwang
  • Youn Jae Lee
  • Mong Cho
  • Jin Mo Yang
  • Young Bae Kim
  • Young Nyun Park
  • Sung Won Cho
Original Article

DOI: 10.1007/s10620-010-1305-3

Cite this article as:
Cheong, J.Y., Um, S.H., Seo, Y.S. et al. Dig Dis Sci (2011) 56: 555. doi:10.1007/s10620-010-1305-3

Abstract

Background/Aims

The majority of non-invasive markers of liver fibrosis have been developed in patients with chronic hepatitis C. We aimed to develop a formula for predicting significant fibrosis in patients with chronic viral hepatitis and to compare the usefulness of published models derived from the data obtained from patients with chronic hepatitis C.

Methods

Serum markers and the METAVIR stage of fibrosis in liver biopsy specimens were compared prospectively in patients with chronic hepatitis B and C (estimation set, 367; validation set, 159).

Results

In the estimation set, multiple forward stepwise logistic regression analysis identified γ-glutamyl transpeptidase, haptoglobin, α2-macroglobulin, matrix metalloproteinase-2, and tissue inhibitor of metalloproteinase-1 as independent predictors of significant fibrosis. A formula termed the SF index was constructed with the aforementioned five variables. The areas under the receiver operating characteristic curves of the SF index for predicting significant fibrosis were 0.828, 0.776, and 0.827 in the estimation, validation, and total sets, respectively. Using cut-off scores of 2.2 and 3.3, significant fibrosis was predicted with considerable accuracy. The diagnostic performances of the SF index and the Zeng index derived from chronic hepatitis B patients were much better than indices derived from chronic hepatitis C patients, such as the APRI, Forns index, and FIB-4.

Conclusions

We developed a novel formula for predicting significant fibrosis in patients with chronic viral hepatitis. Serum indices from studies in patients with chronic hepatitis C were less accurate in patients with chronic hepatitis B for predicting significant fibrosis.

Keywords

Chronic hepatitisLiver fibrosisFibrosis marker

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jae Youn Cheong
    • 1
  • Soon Ho Um
    • 2
  • Yeon Seok Seo
    • 2
  • Dong Joon Kim
    • 3
  • Seong Gyu Hwang
    • 4
  • Youn Jae Lee
    • 5
  • Mong Cho
    • 6
  • Jin Mo Yang
    • 7
  • Young Bae Kim
    • 8
  • Young Nyun Park
    • 9
  • Sung Won Cho
    • 1
  1. 1.Department of GastroenterologyAjou University School of MedicineSuwonSouth Korea
  2. 2.Department of Internal MedicineKorea University College of MedicineSeoulSouth Korea
  3. 3.Department of Internal MedicineHallym University College of MedicineChuncheonSouth Korea
  4. 4.Department of Internal MedicinePochon CHA University College of MedicineSungnamSouth Korea
  5. 5.Department of Internal MedicineInje University College of MedicinePusanSouth Korea
  6. 6.Department of Internal MedicinePusan National University College of MedicinePusanSouth Korea
  7. 7.Department of Internal MedicineCatholic University College of MedicineSuwonSouth Korea
  8. 8.Department of PathologyYonsei University College of MedicineSeoulSouth Korea
  9. 9.Department of PathologyAjou University School of MedicineSuwonSouth Korea