Digestive Diseases and Sciences

, Volume 55, Issue 10, pp 2977–2981

Incidence, Severity, and Etiology of Drug-Induced Acute Pancreatitis

  • Ilona Vinklerová
  • Michal Procházka
  • Vlastimil Procházka
  • Karel Urbánek
Original Article

DOI: 10.1007/s10620-010-1277-3

Cite this article as:
Vinklerová, I., Procházka, M., Procházka, V. et al. Dig Dis Sci (2010) 55: 2977. doi:10.1007/s10620-010-1277-3

Abstract

Introduction

Drug-induced acute pancreatitis is considered to be a rare diagnosis. The incidence of drug-induced acute pancreatitis is usually estimated from case reports.

Aim

The aim of this study was to determine the incidence, etiology, and severity of drug-induced pancreatitis during a 2-year period in a tertiary hospital.

Methods

The study was conducted as a retrospective analysis of all cases of pancreatitis in the University Hospital in Olomouc (1,432 beds) in 2006–2007. All cases of acute pancreatitis were re-evaluated and divided according to the causative factor. In drug-induced cases, the WHO Probability Scale for the evaluation of causality relationship was used.

Results

The inclusion criteria were met by 170 medical files. There were 91 (53%) cases in men and 79 (47%) in women, and mean age was 57 years old (5–91 years old). The etiology was in 53% biliary, 31% alcohol-induced, 12% other determined, and in 4% the cause could not be established. The proportion of drug-induced acute pancreatitis was 5.3% and it was the third most frequent cause of the AP. Azathioprine was the most frequent causative factor (three cases in two patients); all the other causative drugs were documented only in single cases: mesalazine, dexamethasone, ramipril, mycophenolate mofetil, cytarabine, and valproate.

Conclusions

The diagnosis of drug-induced acute pancreatitis seems to be underestimated because of the difficulties in determining the causative agent and the need for a retrospective re-evaluation of the suspected causative factors. The disease is more probable in younger persons, women, and patients suffering from Crohn’s disease.

Keywords

Acute pancreatitisDrug-induced pancreatitisAdverse drug reactionsRetrospective studyAzathioprineCrohn’s disease

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ilona Vinklerová
    • 1
  • Michal Procházka
    • 1
  • Vlastimil Procházka
    • 1
  • Karel Urbánek
    • 2
  1. 1.2nd Department of Internal Medicine, Faculty of Medicine and University HospitalPalacký UniversityOlomoucCzech Republic
  2. 2.Department of Pharmacology, Faculty of Medicine and University HospitalPalacký UniversityOlomoucCzech Republic