, Volume 55, Issue 5, pp 1197-1199
Date: 08 Apr 2010

Chronic Hepatitis C and Chronic Kidney Disease

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Chronic kidney disease (CKD) has long been under-detected. The benefits of early detection include earlier treatment and patient education, so that co-morbidities associated with CKD can be prevented, and progression to end-state kidney disease can be slowed down. This is particularly relevant to chronic disease states that are known to be associated with CKD, such as chronic hepatitis C. In the manuscript titled “Increased prevalence of reduced estimated glomerular filtration rate in chronic hepatitis C” by Petre et al. [1], the authors analyzed a cohort of 831 consecutive patients in the outpatient clinic with chronic hepatitis C to assess the prevalence of reduced estimated glomerular filtration (eGFR). The authors reported that more than half of patients had depressed eGFR, with a predominance of patients (36.4%) in the GFR range of stage 2 CKD (60–89 ml/min/1.73 m2). In contrast, only one-third of patients had estimated creatinine clearance <90 ml/min/1.73 m2 if the Cockcroft–Gaul ...