Digestive Diseases and Sciences

, Volume 55, Issue 5, pp 1450–1457

Increased Prevalence of Reduced Estimated Glomerular Filtration Rate in Chronic Hepatitis C Patients

  • Sorin A. Petre
  • Mankanwal S. Sachdev
  • Brie N. Noble
  • Marianne Rosati
  • Marek J. Mazur
  • Raymond L. Heilman
  • M. Edwyn Harrison
  • David D. Douglas
  • Vijayan Balan
Original Article

DOI: 10.1007/s10620-010-1170-0

Cite this article as:
Petre, S.A., Sachdev, M.S., Noble, B.N. et al. Dig Dis Sci (2010) 55: 1450. doi:10.1007/s10620-010-1170-0

Abstract

Background

To investigate the prevalence and severity of reduced estimated glomerular filtration rate (eGFR) in patients with chronic hepatitis C (CHC).

Methods

Medical record review of 831 consecutive CHC patients seen in our clinic between July 2000 and August 2003; eGFR was estimated using the abbreviated Modification of Diet in Renal Disease (aMDRD) equation. The stage of kidney disease was determined based on eGFR expressed in milliliters per minute per 1.73 m2: stage 1 (signs of kidney damage but normal or elevated (eGFR ≥ 90), stage 2 (eGFR 60–89), stage 3 (30–59), stage 4 (eGFR 15–29), stage 5 (eGFR < 15 or dialysis-dependent).

Results

A total of 522 patients had available data with using the aMDRD equation, 51% had abnormal eGFR (stage 1, 4.6%; stage 2, 36.4%; stage 3 or 4, 6.1%; stage 5, 3.8%). Of 190 patients with stage 2 kidney disease, 189 patients (99.5%) had normal serum creatinine and only one patient (0.5%) had elevated creatinine concentrations (>1.4 mg/dl). Of the 32 patients with stage 3 or 4 disease, 20 (62.5%) had a normal serum creatinine concentration. Of 349 patients without diseases known to cause renal insufficiency, 38% had stage 2–4 renal disease. In a subset of these patients, 95/522 (18%) the measured creatinine clearance showed good correlation with their aMDRD (R = 0.47, (p < 0.0001).

Conclusions

In CHC patients, a normal serum creatinine concentration does not assure normal kidney function. Estimation of eGFR with the aMDRD equation is a more accurate method of identifying patients with chronic kidney disease and reduced eGFR. Therefore, CHC patients should be screened more rigorously for chronic kidney disease because of the high prevalence of reduced eGFR. Lastly, in all CHC patients, the aMDRD eGFR should be used in each encounter with these patients when assessing their renal function irrespective of their serum creatinine.

Keywords

Chronic kidney disease Hepatitis C Screening methods 

Abbreviations

ALT

Alanine aminotransferase

aMDRD

Abbreviated Modification of Diet in Renal Disease

AST

Aspartate aminotransferase

bDNA

Branched-chain DNA

CHC

Chronic hepatitis C

CI

Confidence interval

CKD

Chronic kidney disease

eGFR

Estimated glomerular filtration rate

ESRD

End-stage renal disease

GFR

Glomerular filtration rate

HCV

Hepatitis C virus

INR

International normalized ratio

KDIGO

Kidney Disease: Improving Global Outcomes

MDRD

Modification of Diet in Renal Disease

NHANES

National Health and Nutrition Examination Survey

SCR

Standardized serum creatinine

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Sorin A. Petre
    • 1
  • Mankanwal S. Sachdev
    • 1
  • Brie N. Noble
    • 2
  • Marianne Rosati
    • 1
  • Marek J. Mazur
    • 1
  • Raymond L. Heilman
    • 1
  • M. Edwyn Harrison
    • 1
  • David D. Douglas
    • 1
  • Vijayan Balan
    • 1
  1. 1.The Division of Transplantation MedicineMayo Clinic HospitalPhoenixUSA
  2. 2.Division of BiostatisticsMayo Clinic HospitalPhoenixUSA

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