Digestive Diseases and Sciences

, Volume 55, Issue 2, pp 384–391

Effect of Meal Ingestion on Ileocolonic and Colonic Transit in Health and Irritable Bowel Syndrome

  • Annemie Deiteren
  • Michael Camilleri
  • Duane Burton
  • Sanna McKinzie
  • Archana Rao
  • Alan R. Zinsmeister
Original Article

DOI: 10.1007/s10620-009-1041-8

Cite this article as:
Deiteren, A., Camilleri, M., Burton, D. et al. Dig Dis Sci (2010) 55: 384. doi:10.1007/s10620-009-1041-8

Abstract

Background

Postprandial symptoms in irritable bowel syndrome (IBS) have been associated with increased bowel contractility.

Aim

To compare ileocolonic and colonic responses to feeding in health and IBS.

Methods

We prospectively analyzed data from separate research trials in 122 IBS patients and 41 healthy volunteers. Ileocolonic transit (ICT) was evaluated before (colonic filling [CF]3h) and immediately after (CF4h) a standard lunch at 3 h 45 min, and 2 h thereafter. The colonic geometric center (GC) was calculated 2 h (GC6h) after lunch ingested at 4 h (GC4h) and directly after (GC8h) a standard dinner ingested at 7 h 45 min.

Results

ICT immediately after eating was higher in IBS diarrhea predominant (IBS-D) patients than in the healthy cohort (23.1 ± 2.4 vs. 17.5 ± 2.8%, P = 0.059). ICT 2 h after lunch was similar between groups (P = 0.55). There was significant overall group differences in colonic transit 2 h post-lunch (P = 0.045), particularly in the IBS constipation predominant (IBS-C; GC6–GC4, Δ0.29 ± 0.08) patients versus healthy volunteers (Δ0.56 ± 0.12 GC units).

Conclusions

After feeding, ICT is increased in IBS-D, whereas colonic transit is blunted in IBS-C.

Keywords

ColonicGastrocolic reflexGastroileal reflexIleocolonicResponse to food

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Annemie Deiteren
    • 1
  • Michael Camilleri
    • 1
  • Duane Burton
    • 1
  • Sanna McKinzie
    • 1
  • Archana Rao
    • 1
  • Alan R. Zinsmeister
    • 2
  1. 1.Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), College of MedicineMayo ClinicRochesterUSA
  2. 2.Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, College of MedicineMayo ClinicRochesterUSA