Original Article

Digestive Diseases and Sciences

, Volume 55, Issue 2, pp 384-391

First online:

Effect of Meal Ingestion on Ileocolonic and Colonic Transit in Health and Irritable Bowel Syndrome

  • Annemie DeiterenAffiliated withClinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), College of Medicine, Mayo Clinic
  • , Michael CamilleriAffiliated withClinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), College of Medicine, Mayo Clinic Email author 
  • , Duane BurtonAffiliated withClinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), College of Medicine, Mayo Clinic
  • , Sanna McKinzieAffiliated withClinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), College of Medicine, Mayo Clinic
  • , Archana RaoAffiliated withClinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), College of Medicine, Mayo Clinic
  • , Alan R. ZinsmeisterAffiliated withDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, College of Medicine, Mayo Clinic

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Abstract

Background

Postprandial symptoms in irritable bowel syndrome (IBS) have been associated with increased bowel contractility.

Aim

To compare ileocolonic and colonic responses to feeding in health and IBS.

Methods

We prospectively analyzed data from separate research trials in 122 IBS patients and 41 healthy volunteers. Ileocolonic transit (ICT) was evaluated before (colonic filling [CF]3h) and immediately after (CF4h) a standard lunch at 3 h 45 min, and 2 h thereafter. The colonic geometric center (GC) was calculated 2 h (GC6h) after lunch ingested at 4 h (GC4h) and directly after (GC8h) a standard dinner ingested at 7 h 45 min.

Results

ICT immediately after eating was higher in IBS diarrhea predominant (IBS-D) patients than in the healthy cohort (23.1 ± 2.4 vs. 17.5 ± 2.8%, P = 0.059). ICT 2 h after lunch was similar between groups (P = 0.55). There was significant overall group differences in colonic transit 2 h post-lunch (P = 0.045), particularly in the IBS constipation predominant (IBS-C; GC6–GC4, Δ0.29 ± 0.08) patients versus healthy volunteers (Δ0.56 ± 0.12 GC units).

Conclusions

After feeding, ICT is increased in IBS-D, whereas colonic transit is blunted in IBS-C.

Keywords

Colonic Gastrocolic reflex Gastroileal reflex Ileocolonic Response to food