Digestive Diseases and Sciences

, Volume 55, Issue 7, pp 1964–1968

Risk of Adverse Clinical Outcomes with Concomitant Use of Clopidogrel and Proton Pump Inhibitors Following Percutaneous Coronary Intervention

Authors

    • Division of GastroenterologyUniversity of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System
  • Darpan Bansal
    • Division of CardiologyUniversity of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System
  • John Sotos
    • Apneos Corporation
  • Kevin Olden
    • Division of GastroenterologyUniversity of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System
Original Article

DOI: 10.1007/s10620-009-0960-8

Cite this article as:
Gupta, E., Bansal, D., Sotos, J. et al. Dig Dis Sci (2010) 55: 1964. doi:10.1007/s10620-009-0960-8

Abstract

Background

Recent studies have suggested that proton pump inhibitors (PPIs) attenuate the benefits of clopidogrel. The clinical relevance of this interaction in patients who have undergone percutaneous coronary intervention (PCI) is unknown. We hypothesized that post-PCI patients discharged on clopidogrel will have higher cardiovascular events if concomitant PPI therapy is used.

Aims

To determine whether post-PCI patients discharged on clopidogrel will have higher cardiovascular events if concomitant PPI therapy is used.

Methods

We reviewed the medical records of all the patients discharged on clopidogrel who underwent PCI from January 2003 to August 2004. The primary outcome studied was a major adverse cardiovascular event (MACE), which was defined as a composite of death, myocardial infarction, and target vessel failure.

Results

Of the 315 post-PCI patients who were discharged on clopidogrel, 72 were discharged on PPI. During a mean follow-up period of 50 months, patients discharged on concomitant clopidogrel-PPI therapy had a MACE rate of 56% (vs. 38% in the clopidogrel alone group) (P = 0.025) and had 95% excess risk of MACE.

Conclusion

Concomitant use of clopidogrel and PPI in post-PCI patients is associated with a higher risk of MACE. This suggests that PPIs may attenuate clopidogrel’s beneficial antiplatelet effect, which is crucial after PCI. Prospective randomized studies are warranted to provide definitive evidence for this interaction.

Keywords

ClopidogrelProton pump inhibitorsPercutaneous coronary interventionDrug interaction

Copyright information

© Springer Science+Business Media, LLC 2009