Digestive Diseases and Sciences

, Volume 54, Issue 11, pp 2312–2317

Potential Anti-inflammatory Effects of Proton Pump Inhibitors: A Review and Discussion of the Clinical Implications

  • Ramalinga R. Kedika
  • Rhonda F. Souza
  • Stuart Jon Spechler
Review

DOI: 10.1007/s10620-009-0951-9

Cite this article as:
Kedika, R.R., Souza, R.F. & Spechler, S.J. Dig Dis Sci (2009) 54: 2312. doi:10.1007/s10620-009-0951-9

Abstract

Proton pump inhibitors (PPIs) are potent blockers of gastric acid secretion, and are widely regarded as the agents of choice for the treatment of acid-peptic disorders. For patients with upper gastrointestinal symptoms of uncertain etiology, improvement with PPI therapy is considered prima facie evidence of a pathogenetic role for acid-peptic disease. In addition to anti-secretory effects, however, PPIs have been found to have anti-oxidant properties and direct effects on neutrophils, monocytes, endothelial, and epithelial cells that might prevent inflammation. Those anti-inflammatory effects of the PPIs might influence a variety of inflammatory disorders, both peptic and non-peptic, within and outside of the gastrointestinal tract. The purpose of this report is to review the mechanisms whereby PPIs might exert anti-inflammatory effects exclusive of gastric acid inhibition, to discuss the clinical implications of those effects, and to emphasize that a clinical response to PPIs should not be construed as proof for an underlying acid-peptic disorder.

Keywords

Proton pump inhibitorsInflammationAnti-inflammatory agentsAnti-oxidantsOxidative stressEosinophilic esophagitis

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Ramalinga R. Kedika
    • 1
    • 2
  • Rhonda F. Souza
    • 1
    • 2
  • Stuart Jon Spechler
    • 1
    • 2
    • 3
  1. 1.VA North Texas Healthcare SystemDallasUSA
  2. 2.The University of Texas Southwestern Medical CenterDallasUSA
  3. 3.Division of GastroenterologyDallas VA Medical CenterDallasUSA