, Volume 55, Issue 6, pp 1791-1793
Date: 06 Aug 2009

Regression of B-Cell Lymphoma of the Liver with Hepatitis C Virus Infection After Treatment with Pegylated Interferon-α and Ribavirin

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Introduction

The pathogenesis of human B-cell lymphoma is not well understood, although some types of B-cell lymphoma seem to be related to infection with pathogens such as Helicobacter pylori [1]. Accumulating evidence reveals a high incidence of B-cell lymphoma in patients with hepatitis C virus (HCV) infection, suggesting a link between HCV infection and the development of B-cell lymphoma [26].

We describe here a case of primary B-cell lymphoma of the liver with HCV infection that regressed following the eradication of HCV.

Case Report

A 73-year-old woman with known HCV infection (high viral load of genotype 2a) was referred to our hospital in November of 2003 for further examination of a liver tumor. Superparamagnetic iron-oxide-enhanced magnetic resonance imaging (MRI) revealed a single nodule about 3 cm in diameter, in the fourth segment (Fig. 1a). Microscopic analysis of the biopsy specimens of the liver tumor demonstrated diffuse infiltration with small atypical lymphoid cells, ma