Digestive Diseases and Sciences

, 55:1

Nitroglycerin in the Prevention of Post-ERCP Pancreatitis: A Meta-Analysis

Authors

  • Li-Ming Shao
    • Department of GastroenterologySecond Affiliated Hospital, College of Medicine, Zhejiang University
  • Qing-Yu Chen
    • Department of GastroenterologySecond Affiliated Hospital, College of Medicine, Zhejiang University
  • Miao-Yan Chen
    • Department of GastroenterologySecond Affiliated Hospital, College of Medicine, Zhejiang University
    • Department of GastroenterologySecond Affiliated Hospital, College of Medicine, Zhejiang University
Review

DOI: 10.1007/s10620-008-0709-9

Cite this article as:
Shao, L., Chen, Q., Chen, M. et al. Dig Dis Sci (2010) 55: 1. doi:10.1007/s10620-008-0709-9

Abstract

The objective of this research paper is to evaluate the effect of prophylactic nitroglycerin in the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) by performing a meta-analysis of randomized controlled trials (RCTs). Electronic databases, including PubMed, EMBASE, the Cochrane library, and the Science Citation Index, were searched to retrieve relevant trials. Outcome measures were the incidence of PEP. Four RCTs, enrolling a total of 856 patients, were included. Meta-analysis of these trials indicated a significant association between the use of nitroglycerin and the reduction of PEP (RR 0.60; 95%CI: 0.39–0.92; P = 0.02). However, subsequent sensitive analysis failed to confirm that nitroglycerin was statistically superior to a placebo in reducing PEP (RR 0.68; 95%CI: 0.41–1.11; P = 0.12). Based on the limitations in this meta-analysis, prophylactic use of nitroglycerine for all patients who underwent ERCP is not recommended. Further clinical trials are required to confirm the effect of nitroglycerin in the prevention of PEP.

Keywords

NitroglycerinPost-ERCP pancreatitisMeta-analysis

Copyright information

© Springer Science+Business Media, LLC 2009