Digestive Diseases and Sciences

, 54:2549

Gastroprotective Action of Cochinchina Momordica Seed Extract Is Mediated by Activation of CGRP and Inhibition of cPLA2/5-LOX Pathway

Authors

  • Jung Mook Kang
    • Department of Internal Medicine and Liver Research InstituteSeoul National University College of Medicine
    • Department of Internal Medicine and Liver Research InstituteSeoul National University College of Medicine
    • Department of Internal MedicineSeoul National University Bundang Hospital
  • Bongcheol Kim
    • Life Science R&D Center, SK Chemicals
  • Joo-Hyon Kim
    • Life Science R&D Center, SK Chemicals
  • Bong-Yong Lee
    • Life Science R&D Center, SK Chemicals
  • Ji Hyun Park
    • Department of Internal Medicine and Liver Research InstituteSeoul National University College of Medicine
  • Mi Kyoung Lee
    • Department of Internal Medicine and Liver Research InstituteSeoul National University College of Medicine
  • Hye Seung Lee
    • Department of PathologySeoul National University Bundang Hospital
  • In-Jin Jang
    • Department of PharmacologySeoul National University College of Medicine
  • Joo Sung Kim
    • Department of Internal Medicine and Liver Research InstituteSeoul National University College of Medicine
  • Hyun Chae Jung
    • Department of Internal Medicine and Liver Research InstituteSeoul National University College of Medicine
  • In Sung Song
    • Department of Internal Medicine and Liver Research InstituteSeoul National University College of Medicine
Original Article

DOI: 10.1007/s10620-008-0671-6

Cite this article as:
Kang, J.M., Kim, N., Kim, B. et al. Dig Dis Sci (2009) 54: 2549. doi:10.1007/s10620-008-0671-6

Abstract

Cochinchina momordica seed extract (SK-MS10), which is composed of the major compounds momordica saponins, has been evaluated for its gastroprotective effects in rat models of acute gastric mucosal damage. Ethanol and water immersion restraint stress (WRS) induced gastric damage, including hemorrhages and edema, was significantly attenuated by pretreatment with SK-MS10. In addition, SK-MS10 reduced increases of mucosal myeloperoxidase (MPO), IL-1β, and TNFα levels and the expression of cPLA2, and 5-LOX induced by ethanol or WRS. SK-MS10 also increased hexosamine, adherent mucus, and the expression of MUC5AC. Furthermore, SK-MS10 enhanced the mucosal expression of the CGRP gene and its serum levels. NG-methyl L-arginine (L-NMMA) or capsaicin desensitization reversed the SK-MS10-induced gastroprotection effect. These results suggest that SK-MS10 is a gastroprotective agent against acute gastric mucosal damage by suppressing proinflammatory cytokines, down-regulating cPLA2, 5-LOX, and increasing the synthesis of mucus. Furthermore, CGRP-NO pathway was found to play an important role in these gastroprotective effects of SK-MS10.

Keywords

Cochinchina momordicaCalcitonin gene-related peptideNitric oxideGastroprotection

Copyright information

© Springer Science+Business Media, LLC 2009