Digestive Diseases and Sciences

, Volume 54, Issue 11, pp 2330–2337

EUS-Guided Celiac Plexus Neurolysis for Pain due to Chronic Pancreatitis or Pancreatic Cancer Pain: A Meta-Analysis and Systematic Review

Authors

    • Division of Gastroenterology and Hepatology, CE443 Clinical Support & EducationUniversity of Missouri-Columbia
  • Jyotsna B. K. Reddy
    • Division of Gastroenterology and Hepatology, CE443 Clinical Support & EducationUniversity of Missouri-Columbia
  • Matthew L. Bechtold
    • Division of Gastroenterology and Hepatology, CE443 Clinical Support & EducationUniversity of Missouri-Columbia
  • Mainor R. Antillon
    • Division of Gastroenterology and Hepatology, CE443 Clinical Support & EducationUniversity of Missouri-Columbia
  • William R. Brugge
    • GI UnitMassachusetts General Hospital
Review

DOI: 10.1007/s10620-008-0651-x

Cite this article as:
Puli, S.R., Reddy, J.B.K., Bechtold, M.L. et al. Dig Dis Sci (2009) 54: 2330. doi:10.1007/s10620-008-0651-x

Abstract

The objective of this study was to evaluate the efficacy of EUS-guided CPN for pain relief in patients with chronic pancreatitis and pancreatic cancer. An initial search identified 1,439 reference articles, of which 130 relevant articles were selected and reviewed. Data was extracted from 8 studies (N = 283) for EUS-guided CPN for pain due to pancreatic cancer and nine studies for chronic pancreatitis (N = 376) which met the inclusion criteria. With EUS-guided CPN, the pooled proportion of patients with pancreatic cancer that showed pain relief was 80.12% (95% CI = 74.47–85.22). In patients with pain due to chronic pancreatitis, EUS-guided CPN provided pain relief in 59.45% (95% CI = 54.51–64.30). In conclusion, EUS-guided CPN offers a safe alternative technique for pain relief in patients with chronic pancreatitis or pancreatic cancer. In patients with pain due to chronic pancreatitis, better techniques or injected materials are needed to improve the response.

Keywords

Endoscopic ultrasoundCeliac plexus neurolysisPancreatic cancerChronic pancreatitisMeta-analysisSystematic review

Abbreviations

CP

Chronic pancreatitis

CPN

Celiac plexus neurolysis

EUS

Endoscopic ultrasound

Copyright information

© Springer Science+Business Media, LLC 2009