Digestive Diseases and Sciences

, 54:1835

The Safety of Histamine 2 (H2) Blockers in Pregnancy: A Meta-analysis

Authors

  • Simerpal Kaur Gill
    • The Motherisk Program, The Hospital for Sick Children
    • Department of PharmacologyUniversity of Toronto
  • Lisa O’Brien
    • The Motherisk Program, The Hospital for Sick Children
    • Institute of Medical Science, University of Toronto
    • The Motherisk Program, The Hospital for Sick Children
    • Department of PharmacologyUniversity of Toronto
    • Institute of Medical Science, University of Toronto
Original Article

DOI: 10.1007/s10620-008-0587-1

Cite this article as:
Gill, S.K., O’Brien, L. & Koren, G. Dig Dis Sci (2009) 54: 1835. doi:10.1007/s10620-008-0587-1

Abstract

Heartburn and acid reflux increase the severity of nausea and vomiting of pregnancy, and may lead to more serious medical conditions. The fetal safety of histamine 2 (H2) blockers, the most common antireflux medication, during pregnancy needs to be determined. The aim herein is to determine the fetal safety of H2 blockers during pregnancy through systematic review. All original research assessing the safety of H2 blockers in pregnancy was sought. Data included congenital malformations, spontaneous abortions, preterm delivery, and small for gestational age. A random-effects model combined results. With data from 2,398 exposed and 119,892 nonexposed to H2 blockers, overall odds ratio was 1.14 [0.89, 1.45]. Further analysis revealed no increased risks for spontaneous abortions, preterm delivery, and small for gestational age with odds ratios and 95% confidence intervals (CIs) of 0.62 [0.36–1.05], 1.17 [0.94, 1.147], and 0.28 [0.06, 1.22], respectively. H2 blockers can be used safely in pregnancy.

Keywords

H2 blockersAcid refluxGERDPregnancyMalformations

Copyright information

© Springer Science+Business Media, LLC 2008