Digestive Diseases and Sciences

, Volume 54, Issue 9, pp 1958–1965

In French Children, Primary Gastritis Is More Frequent Than Helicobacter pylori Gastritis

  • N. Kalach
  • S. Papadopoulos
  • E. Asmar
  • C. Spyckerelle
  • P. Gosset
  • J. Raymond
  • E. Dehecq
  • A. Decoster
  • C. Creusy
  • C. Dupont
Original Article

DOI: 10.1007/s10620-008-0553-y

Cite this article as:
Kalach, N., Papadopoulos, S., Asmar, E. et al. Dig Dis Sci (2009) 54: 1958. doi:10.1007/s10620-008-0553-y

Abstract

The aim of this study was to analyze the histological characteristics according to the updated Sydney classification (intensity of gastritis, degree of activity, gastric atrophy, intestinal metaplasia, and Helicobacter pylori) in symptomatic children referred for upper gastrointestinal endoscopy. A 4-year retrospective descriptive study was carried out in 619 children (282 females and 337 males), median age 3.75 years (15 days to 17.3 years) referred for endoscopy. Six gastric biopsies were done (three antrum and three corpus) for histological analysis (n = 4), direct examination and H. pylori culture (n = 2). H. pylori status was considered positive if at least two out of three tests were positive and negative if all three tests were negative. The results showed that only 66 children (10.66%) were H. pylori positive. Histological antral and corpus gastritis was detected in, respectively, 53.95% and 59.12% of all cases, most of them of mild grade 1. Antral and corpus activity was grade 1 in 18.57% and 20.03% of cases. H. pylori-positive versus H. pylori-negative children did differ in terms of moderate and marked histological gastritis and grade 2 or 3 activities. One girl had moderate gastric atrophy and another one moderate intestinal metaplasia, both being H. pylori negative. The findings indicate that primary antrum and corpus gastritis is 5.3 and 6.9 times, respectively, more frequent than H. pylori gastritis in French children, with usually mild histological gastritis and activity. Gastric atrophy and intestinal metaplasia are rare.

Keywords

Helicobacter pyloriChildrenGastritisActivityPrimaryGastric atrophyIntestinal metaplasiaSydney classification

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • N. Kalach
    • 1
    • 2
  • S. Papadopoulos
    • 3
  • E. Asmar
    • 1
  • C. Spyckerelle
    • 1
  • P. Gosset
    • 3
  • J. Raymond
    • 4
  • E. Dehecq
    • 5
  • A. Decoster
    • 5
  • C. Creusy
    • 3
  • C. Dupont
    • 2
  1. 1.Department of Pediatrics, Saint Antoine Paediatric Clinic, Saint Vincent de Paul HospitalCatholic University of LilleLille CedexFrance
  2. 2.Department of Pediatrics, Neonatalogy Cochin-Saint Vincent de Paul HospitalUniversity Paris DescartesParis France
  3. 3.Department of Pathology, Saint Vincent de Paul HospitalCatholic University of LilleLille Cedex France
  4. 4.Department of Microbiology, Cochin-Saint Vincent de Paul HospitalUniversity Paris DescartesParis France
  5. 5.Department of Microbiology, Saint Philibert HospitalCatholic University of Lille Lille CedexFrance