Hepatic Venous Pressure Gradient: Worth Another Look?
- Sameer ParikhAffiliated withDepartment of Medicine, Baylor College of Medicine Email author
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Portal hypertension is one of the most important complications of chronic liver disease and accounts for significant morbidity and mortality. Measurement of the hepatic venous pressure gradient (HVPG) is a simple, invasive, and reproducible method of assessing portal venous pressure. Measurement of HVPG provides the clinician an estimate of the degree of intrahepatic portal flow resistance, guides therapy for variceal bleeding (primary and secondary prophylaxis), assesses feasibility of resection in patients with hepatocellular cancer, and predicts response to therapy of patients with chronic hepatitis C. Achieving hemodynamic targets of reducing the HVPG to <10 mmHg or a 20% reduction from baseline virtually eliminates complications related to portal hypertension from chronic liver disease. This review explores the role of HVPG measurement in the contemporary treatment of patients with cirrhosis and portal hypertension.
KeywordsCirrhosis Portal hypertension Variceal bleeding Liver function tests
- Hepatic Venous Pressure Gradient: Worth Another Look?
Digestive Diseases and Sciences
Volume 54, Issue 6 , pp 1178-1183
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Portal hypertension
- Variceal bleeding
- Liver function tests
- Industry Sectors
- Sameer Parikh (1)
- Author Affiliations
- 1. Department of Medicine, Baylor College of Medicine, One Baylor Plaza, BCM Mailstop: 285, Houston, TX, 77030, USA