Digestive Diseases and Sciences

, Volume 54, Issue 6, pp 1178–1183

Hepatic Venous Pressure Gradient: Worth Another Look?

Review

DOI: 10.1007/s10620-008-0491-8

Cite this article as:
Parikh, S. Dig Dis Sci (2009) 54: 1178. doi:10.1007/s10620-008-0491-8

Abstract

Portal hypertension is one of the most important complications of chronic liver disease and accounts for significant morbidity and mortality. Measurement of the hepatic venous pressure gradient (HVPG) is a simple, invasive, and reproducible method of assessing portal venous pressure. Measurement of HVPG provides the clinician an estimate of the degree of intrahepatic portal flow resistance, guides therapy for variceal bleeding (primary and secondary prophylaxis), assesses feasibility of resection in patients with hepatocellular cancer, and predicts response to therapy of patients with chronic hepatitis C. Achieving hemodynamic targets of reducing the HVPG to <10 mmHg or a 20% reduction from baseline virtually eliminates complications related to portal hypertension from chronic liver disease. This review explores the role of HVPG measurement in the contemporary treatment of patients with cirrhosis and portal hypertension.

Keywords

CirrhosisPortal hypertensionVariceal bleedingLiver function tests

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Department of MedicineBaylor College of MedicineHoustonUSA