Digestive Diseases and Sciences

, Volume 53, Issue 11, pp 2904–2908

Mannan-binding Lectin (MBL) Polymorphism and Gastric Cancer Risk in Japanese Population

  • Fang-Yu Wang
  • Tomomitsu Tahara
  • Tomiyasu Arisawa
  • Tomoyuki Shibata
  • Hiromi Yamashita
  • Masakatsu Nakamura
  • Daisuke Yoshioka
  • Masaaki Okubo
  • Naoko Maruyama
  • Toshiaki Kamano
  • Yoshio Kamiya
  • Masahiko Nakamura
  • Hiroshi Fujita
  • Mitsuo Nagasaka
  • Masami Iwata
  • Kazuya Takahama
  • Makoto Watanabe
  • Hiroshi Nakano
  • Ichiro Hirata
Original Paper

DOI: 10.1007/s10620-008-0249-3

Cite this article as:
Wang, FY., Tahara, T., Arisawa, T. et al. Dig Dis Sci (2008) 53: 2904. doi:10.1007/s10620-008-0249-3

Abstract

Background Mannan-binding lectin (MBL) is believed to be an important constituent of the innate immune system. It has been reported that the codon 54 G/A polymorphism of exon-1 affects the MBL2 gene and alters its activity. Aims We investigated the association between polymorphism of the MBL2 gene and gastric cancer risk as well as Helicobacter pylori infection in a Japanese population. Methods The study cohort comprised 388 gastric cancer patients and 144 healthy volunteers. Polymorphism at codon 54 of exon 1 of the MBL2 gene was investigated by PCR-based restriction fragment length polymorphism analysis. Results There was no significant difference in the distribution of the MBL2 genotype among the gastric cancer patients and healthy controls. However, the carrier of the A allele was more prevalent among patients with a more advanced stage gastric cancer [odds ratio (OR) 1.68, 95% confidence interval (CI) 1.05–2.67; P = 0.03] and also had an increased risk of gastric cancer among patients 65 years of age or younger (OR = 1.6, 95%CI = 1.01–2.52, <0.05). Conclusion The codon 54 polymorphism of the MBL2 gene is associated with more advanced phenotypes of gastric cancer and the risk of gastric cancer in Japanese patients 65 years of age or younger.

Keywords

Gastric cancer Helicobacter pylori Mannan-binding lectin Polymorphism 

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Fang-Yu Wang
    • 1
    • 2
  • Tomomitsu Tahara
    • 1
  • Tomiyasu Arisawa
    • 1
  • Tomoyuki Shibata
    • 1
  • Hiromi Yamashita
    • 1
  • Masakatsu Nakamura
    • 1
  • Daisuke Yoshioka
    • 1
  • Masaaki Okubo
    • 1
  • Naoko Maruyama
    • 1
  • Toshiaki Kamano
    • 1
  • Yoshio Kamiya
    • 1
  • Masahiko Nakamura
    • 1
  • Hiroshi Fujita
    • 1
  • Mitsuo Nagasaka
    • 1
  • Masami Iwata
    • 1
  • Kazuya Takahama
    • 1
  • Makoto Watanabe
    • 1
  • Hiroshi Nakano
    • 1
    • 3
  • Ichiro Hirata
    • 1
  1. 1.Department of GastroenterologyFujita Health University School of MedicineKutsukake-cho, ToyoakeJapan
  2. 2.Department of Gastroenterology, Jinling HospitalNanjing University School of MedicineNanjingChina
  3. 3.Fujita Health University School of MedicineKutsukake-cho, ToyoakeJapan