, Volume 53, Issue 4, pp 905-911
Date: 13 Feb 2008

Tonic and Phasic Pyloric Activity in Response to CCK-Octapeptide

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Abstract

Background The purpose of this study was to determine whether a high-resolution solid-state catheter system could detect regional pressure changes within the antrum and pylorus in response to CCK-octapeptide. Methods Subjects received a 30 min infusion of CCK-octapeptide at either 0.02 or 0.06 μg kg−1 h−1. Results Five males and two females were studied. Mean antral pressure during phase I MMC increased from 5.3 ± 2.1 to 9.9 ± 2.4 mmHg (P = 0.028) after infusion. At the pylorus, only the 0.06 μg kg−1 h−1 dose increased tonic pressure (8.8 ± 1.4 to 17.6 ± 2.0 mmHg; P = 0.01) as compared with the 0.02 μg kg−1 h−1 dose (4.7 ± 0.7 to 7.3 ± 0.4 mmHg; P = NS). The peak pressure of pyloric phasic pressure waves was 153 ± 28.4 mmHg and their frequency was 4.9 ± 1.1 contractions min−1. Conclusions CCK-octapeptide elicits both tonic and phasic activity of the pyloric sphincter. The contractile response to a dose of 0.06 μg kg−1 h−1 is greater than the response to 0.02 μg kg−1 h−1.