Digestive Diseases and Sciences

, Volume 53, Issue 4, pp 1100–1106

Assessment of the PHQ-9 as a Screening Tool for Depression in Patients with Chronic Hepatitis C

Original Paper

DOI: 10.1007/s10620-007-9985-z

Cite this article as:
Dbouk, N., Arguedas, M.R. & Sheikh, A. Dig Dis Sci (2008) 53: 1100. doi:10.1007/s10620-007-9985-z


Background and Objectives We examined the test characteristics of the PHQ-9, a new screening tool that has been validated in the general population but not amongst patients with hepatitis C virus (HCV). Methods The PHQ-9, CES-D and BDI-II questionnaires were administered to 129 consecutive patients with chronic HCV attending a specialty clinic between August 2005 and April 2006. Results Approximately 52% of participants reported symptoms suggesting depression. Prevalence of depression was 62% using the BDI-II, 75% per the PHQ-9 and 72% per the CES-D. We observed a strong correlation between the BDI-II, CES-D and PHQ-9 in patients on and off interferon. Scores on the three questionnaires were only moderately associated with symptoms reported by the patients. There was moderate agreement between the CES-D and BDI-II and slight agreement between both these questionnaires and the PHQ-9. Scores on the PHQ-9 correlated strongly with scores on the CES-D and BDI-II and moderately with patients’ symptoms.


ChronicHepatitis CScreeningDepressionQuestionnaire Interferon

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Nader Dbouk
    • 1
  • Miguel R. Arguedas
    • 2
  • Aasim Sheikh
    • 3
  1. 1.Department of Internal MedicineThe University of Alabama at BirminghamBirminghamUSA
  2. 2.Department of Internal Medicine, Division of Gastroenterology and HepatologyThe University of Alabama at BirminghamAlabamaUSA
  3. 3.NW Georgia GastroenterologyMariettaUSA