Digestive Diseases and Sciences

, Volume 53, Issue 4, pp 1107–1113

Response of Combination Therapy on Viral Load and Disease Severity in Chronic Hepatitis C

  • Deepak Kumar
  • Abdul Malik
  • Mohammad Asim
  • Anita Chakravarti
  • Rakha H. Das
  • Premashis Kar
Original Paper

DOI: 10.1007/s10620-007-9960-8

Cite this article as:
Kumar, D., Malik, A., Asim, M. et al. Dig Dis Sci (2008) 53: 1107. doi:10.1007/s10620-007-9960-8

Abstract

Influence of genotypes on viral kinetics and disease severity in chronic hepatitis C (CH-C) patients has been implicated, but requires further investigation. The 41 HCV patients were genotyped by restriction fragment length polymorphism and included for 48 weeks of combination therapy on the basis of clinical (alanine amino transferase ≥60 IU/l) and histological features (histological activity index ≥3). A significant number (30/41) of patients (6/9 of genotype 1, 23/30 of genotype 3 and 1/2 of mixed genotype) attain sustained virological response despite high viral load at baseline. More aggressive treatment was required in genotype 1 than in genotype 3 due to slow response rate. Significant (P < 0.05) difference in the viral load of sustained virological responder and non-responder (NR) was observed after 12 weeks of therapy. Severe course of liver disease was observed in 81.81% (9/11) of NR patients at baseline. Data indicate that genotype 1 was a slow responder compared to genotype 3 on combination therapy. Response to combination therapy was almost independent of baseline viral load. However, a positive correlation of viral load with disease severity was observed. The viral kinetics at 12 weeks is an important tool for determination of virological response.

Keywords

Hepatitis C virusRFLPVirological responseInterferon therapyHistological activity index

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Deepak Kumar
    • 1
    • 2
    • 3
  • Abdul Malik
    • 1
  • Mohammad Asim
    • 1
  • Anita Chakravarti
    • 2
  • Rakha H. Das
    • 3
  • Premashis Kar
    • 1
    • 4
  1. 1.Department of MedicineMaulana Azad Medical CollegeNew DelhiIndia
  2. 2.Department of MicrobiologyMaulana Azad Medical CollegeNew DelhiIndia
  3. 3.Comparative genomics UnitInstitute of Genomics and Integrative BiologyDelhiIndia
  4. 4.New DelhiIndia