Digestive Diseases and Sciences

, Volume 53, Issue 1, pp 242–247

Serum Interleukin-6, Soluble Interleukin-6 Receptor and Crohn’s Disease Activity

  • Stéphane Nancey
  • Nadim Hamzaoui
  • Driffa Moussata
  • Ivan Graber
  • Jacques Bienvenu
  • Bernard Flourie
Original Paper

DOI: 10.1007/s10620-007-9849-6

Cite this article as:
Nancey, S., Hamzaoui, N., Moussata, D. et al. Dig Dis Sci (2008) 53: 242. doi:10.1007/s10620-007-9849-6

Abstract

The relationship between plasma interleukin-6 (IL-6) concentration and its soluble receptor in Crohn’s disease (CD) is not well elucidated. Twenty healthy volunteers and 94 consecutive patients with CD (44 in relapse and 50 in remission) were studied. Plasma IL-6 concentrations in patients with active disease [80 ± 9 pg/ml; mean ± standard error of the mean (SEM)] were significantly higher than in patients with inactive disease (50 ± 4 pg/ml; P < 0.001) or controls (3 ± 1 pg/ml; P < 0.001). However, concentrations did not vary with the severity of CD attacks. Plasma concentrations of soluble interleukin-6 receptor (sIL-6R) in active-CD patients (77 ± 5 ng/ml) did not differ significantly from those with inactive disease (82 ± 5 ng/ml), while both groups had significantly raised concentrations compared with those of controls (58 ± 6 ng/ml; P < 0.03 and P < 0.01, respectively). Plasma IL-6 concentrations correlated significantly with serum C-reactive protein (CRP) (r = 0.34; P < 0.001), whereas plasma sIL-6R concentrations did not. Taken together, these data suggest that, although IL6 and sIL6-R are both involved in the inflammatory process of CD, they are poor markers of disease activity.

Keywords

Crohn’s disease Disease activity Interleukin-6 Soluble IL-6 receptor 

Abbreviations

APP

Acute-phase protein

CD

Crohn’s disease

ELIA

Enzyme–ligand immunoassay

ELISA

Enzyme-linked immunosorbent assay

ESR

Erythrocyte sedimentation rate

IL-6

Interleukin-6

IL-6R

Interleukin-6 receptor

sIL-6R

Soluble interleukin-6 receptor

5-ASA

5-aminosalicylate acid

GMCSF

Granulocyte macrophage colony stimulating factor

HSF

Hepatocyte stimulating factor

LIF/HILDA

Leukemia inhibitory factor/Human interleukin for DA cells

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Stéphane Nancey
    • 1
  • Nadim Hamzaoui
    • 1
  • Driffa Moussata
    • 1
  • Ivan Graber
    • 1
  • Jacques Bienvenu
    • 2
  • Bernard Flourie
    • 1
  1. 1.Department of Gastroenterology, Hospices Civils de LyonCentre Hospitalier Lyon-SudPierre-BéniteFrance
  2. 2.Department of Immunology, Hospices Civils de LyonCentre Hospitalier Lyon-SudPierre-BéniteFrance

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