Digestive Diseases and Sciences

, Volume 52, Issue 11, pp 2920–2925

A Meta-Analysis of Antibiotic Therapy for Active Ulcerative Colitis

Authors

  • Roja Rahimi
    • Faculty of Pharmacy and Pharmaceutical Sciences Research CenterTehran University of Medical Sciences
  • Shekoufeh Nikfar
    • Drug Selecting CommitteeFood and Drug Organization
  • Ali Rezaie
    • Department of Community Health Sciences, Faculty of MedicineUniversity of Calgary
    • Faculty of Pharmacy and Pharmaceutical Sciences Research CenterTehran University of Medical Sciences
    • Department of Toxicology & Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sciences Research CenterTehran University of Medical Sciences
Original paper

DOI: 10.1007/s10620-007-9760-1

Cite this article as:
Rahimi, R., Nikfar, S., Rezaie, A. et al. Dig Dis Sci (2007) 52: 2920. doi:10.1007/s10620-007-9760-1

Abstract

To systematically evaluate the efficacy of antibacterial therapy in ulcerative colitis, we carried out a meta-analysis of controlled clinical trials. Within the time period 1966 through September 2006, PUBMED, EMBASE, and SCOPUS were searched for clinical trial studies that investigated the efficacy of antibiotics in ulcerative colitis. We considered clinical remission as our key outcome of interest. Of 122 studies, 10 randomized placebo-controlled clinical trials matched our criteria and were included in the analysis (530 patients). All the studies used antibiotics as an adjunct therapy to conventional treatment of ulcerative colitis (i.e., corticosteroids and 5-aminosalycilic acid). Pooling of these trials yielded odds ratio (OR) of 2.14 (95% confidence interval [CI], 1.48–3.09; P<0.0001) in favor of antimicrobial therapy. Meta-analysis of short-term trials (5–14 days) showed a higher rate of clinical remission in patients treated with antibiotics (OR, 2.02; 95% CI, 1.36–3). These results suggest that adjunctive antibacterial therapy is effective for induction of clinical remission in ulcerative colitis.

Keywords

Ulcerative colitisAntibioticsClinical remissionMeta-analysis

Copyright information

© Springer Science+Business Media, LLC 2007